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本文引用的文献

1
Treponema denticola interactions with host proteins.齿密螺旋体与宿主蛋白的相互作用。
J Oral Microbiol. 2012;4. doi: 10.3402/jom.v4i0.9929. Epub 2012 Feb 21.
2
Virulence factors of the oral spirochete Treponema denticola.口腔密螺旋体Treponema denticola 的毒力因子。
J Dent Res. 2011 Jun;90(6):691-703. doi: 10.1177/0022034510385242. Epub 2010 Oct 12.
3
Virulence factors of Treponema denticola.齿垢密螺旋体的毒力因子。
Periodontol 2000. 2010 Oct;54(1):117-35. doi: 10.1111/j.1600-0757.2009.00345.x.
4
Structural characterization of Haemophilus parainfluenzae lipooligosaccharide and elucidation of its role in adherence using an outer core mutant.副流感嗜血杆菌脂寡糖的结构表征及其外核心突变体在黏附中作用的阐明
Can J Microbiol. 2008 Nov;54(11):906-17. doi: 10.1139/w08-082.
5
Treponema denticola lipooligosaccharide activates gingival fibroblasts and upregulates inflammatory mediator production.齿垢密螺旋体脂寡糖激活牙龈成纤维细胞并上调炎症介质的产生。
J Cell Physiol. 2008 Sep;216(3):727-31. doi: 10.1002/jcp.21447.
6
Outer membrane protein UspA1 and lipooligosaccharide are involved in invasion of human epithelial cells by Moraxella catarrhalis.外膜蛋白UspA1和脂寡糖参与了卡他莫拉菌对人上皮细胞的侵袭。
Microbes Infect. 2008 Jan;10(1):3-11. doi: 10.1016/j.micinf.2007.09.014. Epub 2007 Oct 2.
7
Binding properties and adhesion-mediating regions of the major sheath protein of Treponema denticola ATCC 35405.具核梭杆菌ATCC 35405主要鞘蛋白的结合特性及黏附介导区域
Infect Immun. 2005 May;73(5):2891-8. doi: 10.1128/IAI.73.5.2891-2898.2005.
8
Binding of Actinobacillus actinomycetemcomitans lipopolysaccharides to Peptostreptococcus micros stimulates tumor necrosis factor alpha production by macrophage-like cells.伴放线放线杆菌脂多糖与微小消化链球菌的结合可刺激巨噬细胞样细胞产生肿瘤坏死因子α。
Oral Microbiol Immunol. 2005 Apr;20(2):118-21. doi: 10.1111/j.1399-302X.2004.00204.x.
9
Loss of lipopolysaccharide receptor CD14 from the surface of human macrophage-like cells mediated by Porphyromonas gingivalis outer membrane vesicles.牙龈卟啉单胞菌外膜囊泡介导人巨噬细胞样细胞表面脂多糖受体CD14的丧失。
Microb Pathog. 2004 Jun;36(6):319-25. doi: 10.1016/j.micpath.2004.02.004.
10
Induction of osteoclastogenesis and matrix metalloproteinase expression by the lipooligosaccharide of Treponema denticola.具核梭杆菌脂寡糖诱导破骨细胞生成及基质金属蛋白酶表达
Infect Immun. 2003 Jan;71(1):226-33. doi: 10.1128/IAI.71.1.226-233.2003.

牙龈密螺旋体脂寡糖的结合特性。

Binding properties of Treponema denticola lipooligosaccharide.

机构信息

Groupe de Recherche en Écologie Buccale, Faculté de Médecine Dentaire, Université Laval, Quebec, Canada.

出版信息

J Oral Microbiol. 2013 Sep 16;5. doi: 10.3402/jom.v5i0.21517. eCollection 2013.

DOI:10.3402/jom.v5i0.21517
PMID:24049558
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3776326/
Abstract

BACKGROUND AND OBJECTIVE

The cell-surface lipooligosaccharide (LOS) of Treponema denticola possesses several biological properties. The aim of this study was to investigate the binding properties of T. denticola LOS to extracellular matrix (ECM) proteins, mucosal cells, and oral bacteria.

DESIGN

LOS was isolated from T. denticola and labeled with tritium. Tritium-labeled LOS was placed in ECM protein-, epithelial cell-, fibroblast-, or bacterium-coated wells of a 96-well microplate. Following incubation, unattached LOS was removed by extensive washing, and the amount of bound LOS was determined by measuring the radioactivity in the wells. Peptostreptococcus micros coated with LOS was used to stimulate fibroblasts, and the secretion of interleukin-6 (IL-6) and interleukin-8 (IL-8) by the fibroblasts was determined by ELISA.

RESULTS

T. denticola LOS had a high affinity for laminin. It also bound to gingival epithelial cells and fibroblasts. Soluble CD14 significantly increased the binding of LOS to fibroblasts. More LOS bound to P. micros than the other oral bacterial species tested. Stimulating fibroblasts with LOS-coated P. micros induced the secretion of IL-6 and IL-8.

CONCLUSIONS

Our study provided evidence that T. denticola LOS possesses the capacity to bind to ECM proteins, mucosal cells, and oral bacteria. In addition, LOS binding to bacteria may increase their pro-inflammatory potential.

摘要

背景与目的

牙龈卟啉单胞菌的细胞表面脂寡糖（LOS）具有多种生物学特性。本研究旨在探讨 T. denticola LOS 与细胞外基质（ECM）蛋白、黏膜细胞和口腔细菌的结合特性。

设计

从 T. denticola 中分离 LOS 并进行氚标记。将氚标记的 LOS 置于 ECM 蛋白、上皮细胞、成纤维细胞或细菌包被的 96 孔微量滴定板孔中。孵育后，通过充分洗涤去除未结合的 LOS，通过测量孔中的放射性来确定结合的 LOS 量。用 LOS 包被的消化链球菌用于刺激成纤维细胞，并通过 ELISA 测定成纤维细胞分泌的白细胞介素-6（IL-6）和白细胞介素-8（IL-8）。

结果

T. denticola LOS 对层粘连蛋白具有高亲和力。它还与牙龈上皮细胞和成纤维细胞结合。可溶性 CD14 显著增加了 LOS 与成纤维细胞的结合。与测试的其他口腔细菌物种相比，更多的 LOS 结合到 P. micros 上。用 LOS 包被的 P. micros 刺激成纤维细胞可诱导 IL-6 和 IL-8 的分泌。

结论

我们的研究提供了证据表明 T. denticola LOS 具有结合 ECM 蛋白、黏膜细胞和口腔细菌的能力。此外，LOS 与细菌的结合可能会增加它们的促炎潜力。