Chen J C, Hämmerer D, Strigaro G, Liou L M, Tsai C H, Rothwell J C, Edwards M J
Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK; Neuroscience Laboratory, Department of Neurology, China Medical University Hospital, Taichung, Taiwan; School of Medicine, China Medical University, Taichung, Taiwan.
Department of Psychology, TU Dresden, Dresden, Germany.
Clin Neurophysiol. 2014 Mar;125(3):585-92. doi: 10.1016/j.clinph.2013.08.007. Epub 2013 Sep 16.
To evaluate the influence of frontal transcranial direct current stimulation (tDCS) on auditory mismatch negativity (MMN).
MMN is an event related potential calculated by subtracting the amplitude of the evoked potentials in response to a "standard" stimulus from the evoked potentials produced by a rare "oddball" stimulus. Here we assessed the influence of anodal tDCS, cathodal tDCS or sham stimulation delivered over the right inferior frontal cortex on MMN in response to duration and frequency auditory deviants in 10 healthy subjects.
MMN to frequency deviants was significantly reduced after anodal tDCS compared with sham or cathodal stimulation which did not change MMN to frequency deviants. Neither anodal nor cathodal tDCS had any effect on MMN to duration deviants.
Non-invasive brain stimulation with tDCS can influence MMN. The differing networks known to be activated by duration and frequency deviants could account for the differential effect of tDCS on duration and frequency MMN.
Non-invasive brain stimulation could be a useful method to manipulate MMN for experimental purposes.
评估额叶经颅直流电刺激（tDCS）对听觉失匹配负波（MMN）的影响。
MMN是一种事件相关电位，通过从罕见的“异常球”刺激产生的诱发电位中减去对“标准”刺激的诱发电位幅度来计算。在此，我们评估了在10名健康受试者中，右侧额下回皮质给予阳极tDCS、阴极tDCS或假刺激对MMN的影响，该MMN是针对持续时间和频率听觉偏差刺激的。
与假刺激或阴极刺激相比，阳极tDCS后对频率偏差刺激的MMN显著降低，而假刺激或阴极刺激并未改变对频率偏差刺激的MMN。阳极和阴极tDCS对持续时间偏差刺激的MMN均无任何影响。
tDCS这种非侵入性脑刺激可影响MMN。已知由持续时间和频率偏差刺激激活的不同神经网络可能解释了tDCS对持续时间和频率MMN的不同影响。
非侵入性脑刺激可能是一种用于实验目的来操控MMN的有用方法。
