Indraccolo U, Scutiero G, Matteo M, Greco P
Complex Operative Unit of Obstetrics and Gynecology of Civitanova Marche Area Vasta 3, Civitanova Marche, Italy -
Minerva Ginecol. 2013 Aug;65(4):465-70.
The aim of this paper was to show that self-assessed anxiety in patients with pelvic visceral discomforts is reduced after the intravaginal administration of adelmidrol.
Twenty-four patients who described themselves as anxious (scoring 5 or more in a 1 to 10 scale in a self-assessment test) and who suffered from pelvic visceral discomfort (during defecation, urination, sexual intercourse and menstruation) were enrolled in the study. Pelvic visceral discomforts were assessed using a questionnaire in which patients were asked to assign a score between 1 and 10 according to intensity. The patients were offered intravaginal adelmidrol therapy (2%, 4.5 mL twice a day for 30 days). The patients were interviewed again and asked to self-assess anxiety and pelvic visceral discomfort at the end of therapy.
12 patients underwent adelmidrol therapy. With the exception of urinary discomfort, all the median scores of pelvic visceral discomforts had improved after 30 days, with significant values achieved for menstruation (P=0.013) and sexual intercourse (P=0.013). Anxiety had also decreased after 30 days (P=0.025), regardless of changes in discomfort levels.
Adelmidrol could selectively modulate the visceral nociceptive pathways (interoception), relieving pelvic discomfort. This action should have an independent effect on anxiety responses.
本文旨在表明，经阴道给予阿德米多醇后，盆腔内脏不适患者的自我评估焦虑感会降低。
24名自述焦虑（在自我评估测试中评分为5分或更高，评分范围为1至10分）且患有盆腔内脏不适（排便、排尿、性交和月经期间）的患者纳入研究。使用问卷评估盆腔内脏不适，要求患者根据强度在1至10分之间打分。为患者提供经阴道阿德米多醇治疗（2%，4.5毫升，每天两次，共30天）。在治疗结束时再次对患者进行访谈，要求他们自我评估焦虑和盆腔内脏不适情况。
12名患者接受了阿德米多醇治疗。除排尿不适外，30天后所有盆腔内脏不适的中位数评分均有所改善，月经（P = 0.013）和性交（P = 0.013）的评分有显著变化。30天后焦虑也有所降低（P = 0.025），与不适程度的变化无关。
阿德米多醇可选择性调节内脏伤害性感受通路（内感受），缓解盆腔不适。这一作用对焦虑反应应有独立影响。
