Departament de Farmacología, Universitat Autònoma de Barcelona, Barcelona, Spain.
BMC Vet Res. 2012 Nov 26;8:230. doi: 10.1186/1746-6148-8-230.
Adelmidrol is a semisynthetic derivative of azelaic acid and analogue of the anti-inflammatory compound palmitoylethanolamide (PEA). Based upon its physicochemical properties, adelmidrol is suitable for topical application. The main objective of the present study was to evaluate the efficacy of a topical adelmidrol emulsion on early and late inflammatory responses in hypersensitive dogs. Repeated intradermal injections of Ascaris suum extract were performed in both lateral thoracic areas of six conscious hypersensitive Beagle dogs, topically treated during 8 consecutive days. Adelmidrol (2%) was applied to one side and vehicle to the other. 24 hours after the last antigen challenge, two biopsies (adelmidrol- and vehicle-treated side) were obtained for each dog at the antigen injection site.
A significant reduction in the antigen-induced wheal areas was observed on the 4th and 7th day of adelmidrol treatment. Moreover, cutaneous mast cell numbers were significantly decreased in biopsies obtained after 8 consecutive days of topical adelmidrol treatment.
The results obtained in the present study show that topical treatment with adelmidrol might represent a new therapeutic tool in controlling the early and late allergic inflammatory skin responses in companion animals.
Adelmidrol 是壬二酸的半合成衍生物，也是抗炎化合物棕榈酸乙醇酰胺（PEA）的类似物。基于其物理化学性质，adelmidrol 适合局部应用。本研究的主要目的是评估局部 adelmidrol 乳剂对超敏犬早期和晚期炎症反应的疗效。在 6 只有意识的超敏比格犬的两侧胸侧区域重复进行了猪蛔虫提取物的皮内注射，连续 8 天进行局部治疗。在一侧应用 adelmidrol（2%），另一侧应用载体。在最后一次抗原挑战后 24 小时，在抗原注射部位为每只狗获取两个活检（adelmidrol 治疗侧和载体治疗侧）。
在 adelmidrol 治疗的第 4 天和第 7 天，观察到抗原诱导的风团面积显著减少。此外，在连续 8 天局部 adelmidrol 治疗后获得的活检中，皮肤肥大细胞数量显著减少。
本研究结果表明，局部应用 adelmidrol 可能代表了一种控制伴侣动物早期和晚期过敏炎症皮肤反应的新治疗工具。
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