Kubus Maciej, Andrzejewska Ewa, Nejc Dariusz, Kobos Józef, Taran Katarzyna
Uniwersytet Medyczny w Łodzi, Klinika Chirurgii i Onkologii Dzieciecej.
Pol Merkur Lekarski. 2013 Aug;35(206):82-4.
Melanocytic skin tumors can be divided into benign nevi and malignant which take the form of melanoma. Melanocytic nevi are common in both adults and children. It is widely acknowledged that they are one of the risk factors of the formation of melanoma. However, melanoma among children is rare. In addition, differentiation of benign and malignant melanocytic tumors is often challenging. Recent studies suggest that COX-2 protein maybe useful in excluding malignant transformation of melanocytic lesion. The aim of the study was to evaluate the occurrence and differences of reactions with COX-2 in groups of nevi in children and melanoma adults.
The study included 75 common nevi and 43 atypical nevi incised in children and 15 cases of melanoma removed in adults. Paraffin blocks were used to make a preparations with routine hematoxylin and eosin staining (H + E) and immunohistochemistry. The results were statistically analyzed.
Positive reactions were observed in both melanocytic nevi and melanoma. Differences between benign and malignant melanocytic tumors were statistically significant. Differences within melanocytic nevi were not statistically significant.
The reactions of COX-2 are present in all nevi and do not allow to differentiate between their various types. COX-2 has potential utility in the differentiation of benign and malignant melanocytic tumors.
黑素细胞性皮肤肿瘤可分为良性痣和恶性黑素瘤。黑素细胞痣在成人和儿童中都很常见。人们普遍认为它们是黑素瘤形成的危险因素之一。然而，儿童黑素瘤很少见。此外，良性和恶性黑素细胞肿瘤的鉴别往往具有挑战性。最近的研究表明，COX - 2蛋白可能有助于排除黑素细胞病变的恶性转化。本研究的目的是评估儿童痣组和成人黑素瘤组中COX - 2反应的发生率及差异。
本研究纳入了75例儿童切除的普通痣和43例非典型痣，以及15例成人切除的黑素瘤。用石蜡块制作常规苏木精和伊红染色（H + E）及免疫组织化学的标本。对结果进行统计学分析。
在黑素细胞痣和黑素瘤中均观察到阳性反应。良性和恶性黑素细胞肿瘤之间的差异具有统计学意义。黑素细胞痣内部的差异无统计学意义。
COX - 2反应存在于所有痣中，无法区分其不同类型。COX - 2在良性和恶性黑素细胞肿瘤的鉴别中具有潜在用途。
