• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

A novel multivalent OspA vaccine against Lyme borreliosis shows promise in Phase I/II studies.

作者信息

Barrett P Noel, Portsmouth Daniel

机构信息

Vaccine R&D, Baxter BioScience, Biomedical Research Centre, Uferstraße 15, A-2304 Orth/Donau, Austria +43 1 20100 244 4316 +43 1 20100 244 5134.

出版信息

Expert Rev Vaccines. 2013 Sep;12(9):973-5. doi: 10.1586/14760584.2013.824704.

DOI:10.1586/14760584.2013.824704
PMID:24053389
Abstract
摘要

相似文献

1
A novel multivalent OspA vaccine against Lyme borreliosis shows promise in Phase I/II studies.一种新型的针对莱姆病的多价OspA疫苗在I/II期研究中显示出前景。
Expert Rev Vaccines. 2013 Sep;12(9):973-5. doi: 10.1586/14760584.2013.824704.
2
The need for a new vaccine against lyme borreliosis.研发新型莱姆病疫苗的必要性。
Expert Rev Vaccines. 2013 Feb;12(2):101-3. doi: 10.1586/erv.12.141.
3
A Novel multivalent OspA vaccine against Lyme borreliosis is safe and immunogenic in an adult population previously infected with Borrelia burgdorferi sensu lato.一种新型的抗莱姆病多价OspA疫苗在先前感染过伯氏疏螺旋体狭义种的成年人群中是安全且具有免疫原性的。
Clin Vaccine Immunol. 2014 Nov;21(11):1490-9. doi: 10.1128/CVI.00406-14. Epub 2014 Sep 3.
4
Safety, immunogenicity, and efficacy of Borrelia burgdorferi outer surface protein A (OspA) vaccine: A meta-analysis.伯氏疏螺旋体外膜蛋白A（OspA）疫苗的安全性、免疫原性及有效性：一项荟萃分析。
J Infect Dev Ctries. 2017 Jan 30;11(1):1-9. doi: 10.3855/jidc.7999.
5
Characterization and optimization of a novel vaccine for protection against Lyme borreliosis.一种新型抗莱姆病疫苗的特性鉴定与优化
Vaccine. 2015 Nov 4;33(44):5982-8. doi: 10.1016/j.vaccine.2015.07.095. Epub 2015 Aug 13.
6
Characterization of recombinant OspA in two different Borrelia vaccines with respect to immunological response and its relationship to functional parameters.两种不同伯氏疏螺旋体疫苗中重组OspA的免疫反应特征及其与功能参数的关系。
BMC Vet Res. 2018 Oct 16;14(1):312. doi: 10.1186/s12917-018-1625-7.
7
Safety and immunogenicity of a novel multivalent OspA vaccine against Lyme borreliosis in healthy adults: a double-blind, randomised, dose-escalation phase 1/2 trial.新型多价 OspA 莱姆病疫苗在健康成年人中的安全性和免疫原性：一项双盲、随机、剂量递增的 1/2 期临床试验。
Lancet Infect Dis. 2013 Aug;13(8):680-9. doi: 10.1016/S1473-3099(13)70110-5. Epub 2013 May 10.
8
Broadly Protective Multivalent OspA Vaccine against Lyme Borreliosis, Developed Based on Surface Shaping of the C-Terminal Fragment.基于 C 末端片段表面重塑的广谱保护性多价 OspA 莱姆病疫苗
Infect Immun. 2020 Mar 23;88(4). doi: 10.1128/IAI.00917-19.
9
Immunization with a recombinant subunit OspA vaccine markedly impacts the rate of newly acquired Borrelia burgdorferi infections in client-owned dogs living in a coastal community in Maine, USA.用重组亚单位OspA疫苗进行免疫接种，对生活在美国缅因州沿海社区的宠物犬新感染伯氏疏螺旋体的比率有显著影响。
Parasit Vectors. 2015 Feb 10;8:92. doi: 10.1186/s13071-015-0676-x.
10
Safety and immunogenicity of a recombinant Borrelia burgdorferi outer surface protein A vaccine against lyme disease in healthy children and adolescents: a randomized controlled trial.重组伯氏疏螺旋体外膜蛋白A疫苗在健康儿童和青少年中预防莱姆病的安全性和免疫原性：一项随机对照试验
Pediatrics. 2001 Jul;108(1):123-8. doi: 10.1542/peds.108.1.123.

引用本文的文献

1
Guidelines for diagnosis and treatment in neurology - Lyme neuroborreliosis.神经病学诊断与治疗指南 - 莱姆神经Borreliosis。
Ger Med Sci. 2020 Feb 27;18:Doc03. doi: 10.3205/000279. eCollection 2020.
2
Cutaneous Lyme borreliosis: Guideline of the German Dermatology Society.皮肤型莱姆病：德国皮肤病学会指南
Ger Med Sci. 2017 Sep 5;15:Doc14. doi: 10.3205/000255. eCollection 2017.
3
The novel Lyme borreliosis vaccine VLA15 shows broad protection against Borrelia species expressing six different OspA serotypes.新型莱姆病疫苗VLA15对表达六种不同OspA血清型的疏螺旋体物种具有广泛的保护作用。
PLoS One. 2017 Sep 1;12(9):e0184357. doi: 10.1371/journal.pone.0184357. eCollection 2017.
4
Identification of a defined linear epitope in the OspA protein of the Lyme disease spirochetes that elicits bactericidal antibody responses: Implications for vaccine development.莱姆病螺旋体OspA蛋白中可引发杀菌性抗体反应的特定线性表位的鉴定：对疫苗开发的意义。
Vaccine. 2017 May 31;35(24):3178-3185. doi: 10.1016/j.vaccine.2017.04.079. Epub 2017 May 4.
5
A systematic review and meta-analysis for the adverse effects, immunogenicity and efficacy of Lyme disease vaccines: Guiding novel vaccine development.莱姆病疫苗不良反应、免疫原性及疗效的系统评价与荟萃分析：指导新型疫苗研发
Can J Public Health. 2017 Apr 20;108(1):e62-e70. doi: 10.17269/cjph.108.5728.
6
Oral Immunization with OspC Does Not Prevent Tick-Borne Borrelia burgdorferi Infection.用OspC进行口服免疫不能预防蜱传伯氏疏螺旋体感染。
PLoS One. 2016 Mar 18;11(3):e0151850. doi: 10.1371/journal.pone.0151850. eCollection 2016.