Department of Radiation Oncology, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan.
BJU Int. 2013 Dec;112(8):1150-5. doi: 10.1111/bju.12402.
To evaluate the association between urinary tract stone (UTS) and urinary tract cancer (UTC) in Taiwanese patients, as the results of epidemiological studies about the relationship between UTS and the development of UTC remain inconclusive.
PATIENTS/SUBJECTS AND METHODS: We conducted a population-based cohort study using data from the Taiwanese National Health Insurance system. The UTS cohort included 21 862 patients, and each patient was randomly frequency-matched for age, sex, and index year with two insured members of the general population who did not have UTS. Cox proportional hazard regression analysis was performed to estimate the effect of UTS on the risk of UTC.
Patients with UTS were at a significantly higher risk of developing UTC compared with the comparison group (adjusted hazard ratio 4.66; 95% confidence interval 2.97-7.30). Women were at higher risk than men. Further analyses showed that the level of UTC was associated with that of UTS, and that the risk for UTC became more divergent for the two groups over time.
Taiwanese patients with UTS, particularly women, had a higher risk for developing UTC than patients without UTS. The risk became more marked over time for this group.
评估台湾地区尿路结石（UTS）与尿路系统癌症（UTC）之间的相关性。因为流行病学研究关于 UTS 与 UTC 发展之间的关系结果仍不一致。
患者/受试者和方法：我们使用来自台湾全民健康保险系统的数据进行了一项基于人群的队列研究。UTS 队列包括 21862 名患者，每位患者按照年龄、性别和索引年份与未患 UTS 的一般人群中的两名参保成员进行随机频率匹配。采用 Cox 比例风险回归分析来估计 UTS 对 UTC 风险的影响。
与对照组相比，患有 UTS 的患者发生 UTC 的风险显著更高（调整后的危险比 4.66；95%置信区间 2.97-7.30）。女性比男性的风险更高。进一步的分析表明，UTC 的水平与 UTS 的水平相关，并且两组之间的风险随着时间的推移变得更加不同。
患有 UTS 的台湾患者，尤其是女性，发生 UTC 的风险高于未患 UTS 的患者。对于该组，这种风险随着时间的推移变得更加明显。
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