Department of Biochemistry, University of Cambridge, Hopkins Building, Tennis Court Road, Cambridge CB2 1QW, UK; Papworth Hospital, Cambridge CB23 3RE, UK.
Heart Fail Clin. 2013 Oct;9(4):373-83, vii. doi: 10.1016/j.hfc.2013.07.011.
The prevalence of both chronic heart failure and atrial fibrillation is increasing as a result of systemic multimorbid risk and improved therapy of acute heart disease. Current treatment options are unsatisfactory especially regarding antiarrhythmic drugs. We propose that a systems biology approach to increase understanding of cardiac arrhythmias offers the best immediate way forward. Such an approach would be based on an accumulation of large clinical datasets, and application of next-generation sequencing in conjunction with selected experimental and computer-based models. Such an approach would in turn facilitate the development and targeted application of currently available and novel therapeutic approaches.
由于系统性多系统风险和急性心脏病治疗的改善，慢性心力衰竭和心房颤动的患病率都在增加。目前的治疗选择并不令人满意，特别是在抗心律失常药物方面。我们提出，采用系统生物学方法来提高对心脏心律失常的认识是当前最有希望的方法。这种方法将基于大量临床数据集的积累，并结合下一代测序技术和选定的实验和计算机模型进行应用。这种方法反过来又将促进目前可用的和新型治疗方法的开发和有针对性的应用。
