Department of Biochemistry and Biophysics, University of Kalyani, Kalyani 741235, West Bengal, India.
FEBS Lett. 2013 Nov 1;587(21):3535-40. doi: 10.1016/j.febslet.2013.09.011. Epub 2013 Sep 18.
Treatment of bovine pulmonary smooth muscle cells with U46619 inhibited the Na(+)/K(+) ATPase activity in two parallel pathways: one of which is mediated via glutathionylation of the pump and the other by augmenting the inhibitory activity of the 70kDa inhibitor protein of Na(+)/K(+) ATPase. Although phospholemman deglutathionylates the pump leading to its activation, the inhibitor is responsible for irreversible inhibition of Na(+)/K(+) ATPase in an isoform specific manner during treatment of the cells with U46619.
用 U46619 处理牛肺平滑肌细胞会抑制钠钾 ATP 酶的活性，这种抑制作用有两条平行的途径：一条是通过泵的谷胱甘肽化介导的，另一条是通过增加钠钾 ATP 酶 70kDa 抑制蛋白的抑制活性来实现的。尽管磷酯酶可以使泵去谷胱甘肽化从而使其激活，但在 U46619 处理细胞的过程中，抑制剂以同工型特异性的方式负责导致钠钾 ATP 酶不可逆抑制。
