Department of Toxicology, Laboratoire National de Santé, Avenue de la Faiencerie, 162 A, L-1511 Luxembourg, Luxembourg.
J Anal Toxicol. 2013 Nov-Dec;37(9):676-9. doi: 10.1093/jat/bkt081. Epub 2013 Sep 19.
Pregabalin is an antiepileptic and analgesic drug, commercialized under the name of Lyrica, and generally used to treat neuropathic pain. The determination of pregabalin was performed by using spiked hair samples extracted in methanol and analyzed by ultra-high-performance liquid chromatography coupled with tandem mass spectrometry. The validation of a quantification method of pregabalin in hair has been successfully achieved (precision, accuracy, matrix effects and extraction yield). The limit of detection was 0.76 pg/mg and the lower limit of quantification was 2.5 pg/mg. A real case of pregabalin in hair has been analyzed using this method. The result showed a concentration of 540 pg/mg.
普瑞巴林是一种抗癫痫和镇痛药，商品名为乐瑞卡，通常用于治疗神经性疼痛。使用甲醇提取的加标头发样本，通过超高效液相色谱-串联质谱法进行普瑞巴林的测定。成功实现了毛发中普瑞巴林的定量方法的验证（精密度、准确度、基质效应和提取效率）。检测限为 0.76 pg/mg，定量下限为 2.5 pg/mg。使用该方法分析了一个头发中普瑞巴林的真实案例。结果显示浓度为 540 pg/mg。
