Li Xiaoming, Luo Qing, Song Guanbin
Key Laboratory of Biorheological Science and Technology, Ministry of Education of China, College of Bioengineering, Chongqing University, Chongqing 400044, China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2013 Aug;30(4):894-8.
Hepatocellular carcinoma (HCC) is one of the most common human malignant tumors worldwide; it is also hard to prevent its metastasis and recurrence by traditional treatments. Up to now, how to prevent and treat HCC is still a challenging problem in clinic. Cancer stem cells (CSCs) are cells within malignant tumor that possess the capacity to self-renew and differentiate to lead to the heterogeneous lineages of cancer cells that comprise the tumor, and are the root to cause metastasis, recurrence and bad prognosis of the cancer. Targeting CSCs is a novel therapeutic strategy for management and treatment of the cancer. In recent years, targeting intervention on liver cancer stem cells (LCSCs) gradually became a novel strategy for HCC treatment, and some exciting research results in the treatment of HCC were also achieved. In this review, we introduce the biological characteristics of LCSCs and highlight the therapeutic strategies for hepatocellular carcinoma by targeting intervention on LCSCs.
肝细胞癌（HCC）是全球最常见的人类恶性肿瘤之一；传统治疗方法也难以预防其转移和复发。到目前为止，如何防治HCC仍然是临床上一个具有挑战性的问题。癌症干细胞（CSCs）是恶性肿瘤内具有自我更新和分化能力的细胞，可导致构成肿瘤的癌细胞产生异质性谱系，是导致癌症转移、复发和预后不良的根源。靶向CSCs是一种治疗癌症的新型策略。近年来，针对肝癌干细胞（LCSCs）的靶向干预逐渐成为HCC治疗的新策略，并且在HCC治疗方面也取得了一些令人振奋的研究成果。在这篇综述中，我们介绍了LCSCs的生物学特性，并重点阐述了通过靶向干预LCSCs治疗肝细胞癌的策略。
