Rebic Damir, Rasic Senija, Rebic Velma
Clinic for Nephrology, Clinical Center of University of Sarajevo , Sarajevo , Bosnia and Herzegovina and.
Ren Fail. 2014 Mar;36(2):232-6. doi: 10.3109/0886022X.2013.836935. Epub 2013 Sep 24.
Left ventricular hypertrophy is the most common structural cardiac alteration in chronic dialysis patients. The aim of this study was to determine the possible association of endotelin-1 (ET-1) and nitric oxide (NO) with parameters of echocardiography in order to assess their participation in left ventricular (LV) remodeling in patients on peritoneal dialysis (PD).
This prospective longitudinal study included 40 PD patients. Serum levels of ET-1 and NO baseline and after 12 months of PD treatment were measured and compared with echocardiography parameters done at the same time of PD treatment. Linear regression analysis was used to detect independent correlations of variables.
Mean ET-1 serum concentration decreased significantly after 12 months of PD treatment compared to baseline values (p < 0.01). NO serum concentration increased significantly 12 months after treatment compared to baseline values (p < 0.01). Left ventricular hypertrophy (LVH) was observed in 72.5% of patients at baseline with significant reduction in LV mass index after 12 months of PD treatment (p < 0.001). On linear regression analysis serum concentration of ET-1 was independent predictors of LV mass index, as well as NO at the end of observed period.
According to our data ET-1 and NO are independently related to the process of left ventricular remodeling in PD patients.
左心室肥厚是慢性透析患者最常见的心脏结构改变。本研究旨在确定内皮素-1（ET-1）和一氧化氮（NO）与超声心动图参数之间可能存在的关联，以评估它们在腹膜透析（PD）患者左心室（LV）重塑中的作用。
这项前瞻性纵向研究纳入了40例PD患者。测量了PD治疗12个月前后ET-1和NO的血清水平，并与PD治疗同期进行的超声心动图参数进行比较。采用线性回归分析来检测变量之间的独立相关性。
与基线值相比，PD治疗12个月后ET-1血清平均浓度显著降低（p < 0.01）。治疗12个月后，NO血清浓度与基线值相比显著升高（p < 0.01）。基线时72.5%的患者观察到左心室肥厚（LVH），PD治疗12个月后左心室质量指数显著降低（p < 0.001）。在线性回归分析中，ET-1血清浓度以及观察期末的NO是左心室质量指数的独立预测因子。
根据我们的数据，ET-1和NO与PD患者左心室重塑过程独立相关。
