Tregaskis B F, Stevenson L H
Department of Pharmacology and Clinical Pharmacology, Ninewells Hospital and Medical School, Dundee, Scotland, UK.
Br Med Bull. 1990 Jan;46(1):9-21. doi: 10.1093/oxfordjournals.bmb.a072397.
All practising clinicians will be aware of the increased number of elderly patients requiring drug treatment as the proportion of people over the age of 65 increases in our Western society. The elderly as a group have much to benefit from modern drug therapy, but, historically, are also the group most prone to adverse drug reactions. Such reactions have often been due to inappropriate drug prescribing based on an incomplete knowledge of changes in drug handling with age. In recent years there has been an increased understanding of the physiological changes of ageing and the changes in drug handling consequent upon these changes. This review will concentrate on the clinical sequelae of changes in drug handling and suggest areas where modification in prescribing practice may yield clinical benefits and lessen the toll of adverse drug reactions.
随着西方社会65岁以上人群比例的增加，所有执业临床医生都会注意到需要药物治疗的老年患者数量在上升。作为一个群体，老年人从现代药物治疗中获益良多，但从历史上看，他们也是最容易发生药物不良反应的群体。这类反应往往是由于对年龄增长导致的药物代谢变化了解不全面而不恰当地开药所致。近年来，人们对衰老的生理变化以及由此导致的药物代谢变化有了更多的认识。本综述将重点关注药物代谢变化的临床后果，并指出在处方实践中进行调整可能带来临床益处并减少药物不良反应危害的领域。
