Uçar Hakan, Gür Mustafa, Kivrak Ali, Koyunsever Nermin Yildiz, Seker Taner, Akilli Rabia Eker, Türkoğlu Caner, Kaypakli Onur, Sahin Durmuş Yildiray, Elbasan Zafer, Tanboğa Halil İbrahim, Cayli Murat
Adana Numune Training and Research Hospital, Department of Cardiology , Adana , Turkey.
Blood Press. 2014 Aug;23(4):240-7. doi: 10.3109/08037051.2013.840429. Epub 2013 Sep 23.
The high-sensitivity cardiac troponin T (hs-cTnT) assay provides important prognostic information on cardiovascular diseases. Although hs-cTnT is associated with left ventricle (LV) hypertrophy (LVH), it has not been investigated in different LV geometric patterns incorporating normal LV structure and concentric remodeling in addition to LVH.
We aimed to investigate the possible association between hs-cTnT and LV geometric patterns in newly diagnosed hypertensive patients.
We studied 306 patients with newly diagnosed hypertension (HT; mean age 51.7 ± 5.6 years) and 44 healthy control subjects (mean age 51.3 ± 4.7 years). Echocardiographic examination was performed in all subjects. Four different geometric patterns were determined in hypertensive patients according to LV mass index (LVMI) and relative wall thickness (RWth). hs-cTnT and other biochemical markers were measured in all participants.
The highest hs-cTnT values were observed in the concentric hypertrophy group compared with the control, normal geometry, concentric remodeling and eccentric hypertrophy groups (p < 0.05, for all). Also, hs-cTnT values of the eccentric hypertrophy group were higher than the control, normal geometry and concentric remodeling groups (p < 0.05, for all). Multivariate regression analysis showed that hs-cTnT was independently associated with LV geometry (β = 0.326, p = 0.001) as well as LVMI (β = 0.228, p = 0.010) and creatinine level β = 0.132, p = 0.012).
hs-cTnT level is related not only to LVH but also to LV geometry in hypertensive patients. hs-cTnT levels may mediate poorer LV geometric patterns in hypertensive patients.
高敏心肌肌钙蛋白T（hs-cTnT）检测可为心血管疾病提供重要的预后信息。虽然hs-cTnT与左心室（LV）肥厚（LVH）有关，但尚未在除LVH之外纳入正常LV结构和向心性重构的不同LV几何模式中进行研究。
我们旨在研究新诊断高血压患者中hs-cTnT与LV几何模式之间的可能关联。
我们研究了306例新诊断高血压（HT；平均年龄51.7±5.6岁）患者和44例健康对照者（平均年龄51.3±4.7岁）。对所有受试者进行了超声心动图检查。根据LV质量指数（LVMI）和相对壁厚度（RWth）在高血压患者中确定了四种不同的几何模式。在所有参与者中测量了hs-cTnT和其他生化标志物。
与对照组、正常几何模式组、向心性重构组和离心性肥厚组相比，向心性肥厚组的hs-cTnT值最高（所有p<0.05）。此外，离心性肥厚组的hs-cTnT值高于对照组、正常几何模式组和向心性重构组（所有p<0.05）。多变量回归分析显示，hs-cTnT与LV几何模式（β=0.326，p=0.001）以及LVMI（β=0.228，p=0.010）和肌酐水平（β=0.132，p=0.012）独立相关。
hs-cTnT水平不仅与高血压患者的LVH有关，还与LV几何模式有关。hs-cTnT水平可能介导高血压患者较差的LV几何模式。
