Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, China; Department of Pathology, University of Arizona College of Medicine, Tucson, AZ, USA.
Gynecol Oncol. 2013 Dec;131(3):555-60. doi: 10.1016/j.ygyno.2013.09.018. Epub 2013 Sep 20.
Recent advances suggest that precancerous lesions of pelvic serous carcinoma (PSC) originate from tubal secretory cells. The purpose of our study was to determine if increased number of secretory cells shows difference in age and location and to examine their association with serous neoplasia.
Three groups (benign control, high-risk, and PSC) of patients with matched ages were studied. The age data was stratified into 10-year intervals ranging from age 20 to older than 80. The number of secretory and ciliated cells from both tubal fimbria and ampulla segments was counted by microscopy and immunohistochemical staining methods. The data was analyzed by standard contingency table and Poisson distribution methods after age justification.
We found that the absolute number of tubal secretory cells increased significantly with age within each age group. Age remained a significant risk factor for serous neoplasia after age adjustment. In addition, a dramatic increase of secretory cells was observed in high-risk and PSC patients. Further, secretory cell expansion (SCE) was more prevalent than secretory cell outgrowth in both fimbria and ampulla tubal segments and was significantly associated with serous neoplasia (p<0.001).
These findings suggest that SCE could potentially serve as a sensitive biomarker for early serous carcinogenesis within the fallopian tube. Findings support a relationship between serous neoplasia and increased secretory to ciliated cell ratios. Findings also support a relationship between frequency of SCE and increasing age, presence of high-risk factors and co-existing serous cancers.
最近的研究进展表明，盆腔浆液性癌（PSC）的癌前病变起源于输卵管分泌细胞。本研究旨在确定分泌细胞数量的增加是否在年龄和位置上存在差异，并研究其与浆液性肿瘤的关系。
研究了三组（良性对照组、高危组和 PSC 组）年龄匹配的患者。将年龄数据分为 10 年一个间隔，从 20 岁到 80 岁以上。通过显微镜和免疫组织化学染色方法计数输卵管伞部和壶腹部段的分泌细胞和纤毛细胞数量。在年龄校正后，使用标准列联表和泊松分布方法对数据进行分析。
我们发现，在每个年龄组内，随着年龄的增长，输卵管分泌细胞的绝对数量显著增加。在年龄调整后，年龄仍然是浆液性肿瘤的一个重要危险因素。此外，在高危和 PSC 患者中观察到分泌细胞的显著增加。此外，在输卵管伞部和壶腹部段的纤毛细胞中，分泌细胞扩张（SCE）比分泌细胞增生更为常见，与浆液性肿瘤显著相关（p<0.001）。
这些发现表明，SCE 可能是输卵管内早期浆液性癌变的敏感生物标志物。研究结果支持浆液性肿瘤与分泌细胞与纤毛细胞比值增加之间的关系。研究结果还支持 SCE 的频率与年龄增加、高危因素存在以及共存浆液性癌之间的关系。
