Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.
Allergol Int. 2013 Dec;62(4):473-8. doi: 10.2332/allergolint.13-OA-0547. Epub 2013 Sep 25.
Eczema in the cubital fossa, which is susceptible to sweat, is frequently observed in atopic dermatitis (AD). However, there has been no direct evidence that sweating causes eczema in the cubital fossa.
To investigate this issue, axon reflex-mediated sweating volume (AXR) and skin barrier function in the cubital fossa were measured in subjects with AD and in healthy volunteers, and were applied to clinical feature of the cubital fossa.
AXR in the cubital fossa decreased in AD subjects; it positively correlated only with water-holding capacity in healthy subjects but not in patients with in AD. Furthermore, AD subjects with lichenoid eczema and either prurigo or papules over the cubital fossa showed extremely decreased AXR.
These results suggest that decreased sweating is a major source of water in the stratum corneum, and decreased sudomotor function may be involved in both the cause and aggravation of representative atopic eczema in the cubital fossa.
肘窝处的湿疹易出汗，常发生于特应性皮炎（AD）。然而，目前尚无直接证据表明出汗会导致肘窝处出现湿疹。
为了研究这个问题，我们测量了 AD 患者和健康志愿者肘窝处的轴突反射介导的出汗量（AXR）和皮肤屏障功能，并将其应用于肘窝的临床特征。
AD 患者肘窝处的 AXR 降低；它仅与健康受试者的保水能力呈正相关，而与 AD 患者则无相关性。此外，患有苔藓样湿疹且肘窝处有瘙痒或丘疹的 AD 患者的 AXR 极低。
这些结果表明，出汗减少是角质层水分的主要来源，而汗腺功能障碍可能与肘窝处特应性湿疹的病因和加重有关。
