Mebs Dietrich, Kordiš Dušan, Kendel Yvonne, Kauferstein Silke
Acta Chim Slov. 2011 Dec;58(4):730-4.
Venoms of the marine cone snails (Conus spp.) consist of numerous proteins and peptides showing a wide variety of biological activities such as on ion-channels and receptors. Peptides acting on neuronal nicotinic acetylcholine receptors belong to several peptide superfamilies including the recently described αD-conopeptides which are homodimers of identical peptides with 47-49 amino acids. Among the venom glands of 27 Conus species analyzed by cDNA cloning, precursors of αD-conopeptides were identified in four species only: C. betulinus, C. capitaneus, C. mustelinus, and C. vexillum. Phylogenetic analysis of the relationships among the αD-conopeptides revealed that they belong to clades, which are characterized by an AVV- and EMM-motif in the signal peptide sequence.
海洋芋螺（Conus spp.）的毒液由众多蛋白质和肽组成，这些蛋白质和肽具有多种生物活性，如作用于离子通道和受体。作用于神经元烟碱型乙酰胆碱受体的肽属于几个肽超家族，包括最近描述的αD -芋螺毒素，它们是由47 - 49个氨基酸的相同肽组成的同型二聚体。在通过cDNA克隆分析的27种芋螺的毒腺中，仅在4种芋螺中鉴定出αD -芋螺毒素的前体：桦斑芋螺（C. betulinus）、船长芋螺（C. capitaneus）、鼬芋螺（C. mustelinus）和旗芋螺（C. vexillum）。对αD -芋螺毒素之间关系的系统发育分析表明，它们属于不同的进化枝，其信号肽序列的特征是具有AVV基序和EMM基序。
