一锅法三组分合成4-（烷基氨基）-7-烷氧基-5-氧代-1-吡啶-2-基-1,5-二氢呋喃并[3,4-b]吡啶-2,3-二羧酸二烷基酯
One-pot, Three-component Synthesis of Dialkyl 4-(alkylamino)-7-alkoxy-5-oxo-1-pyridine-2-yl-1,5-dihydrofuro[3,4-b]pyridine-2,3-dicarboxylate.
作者信息
Asghari Sakineh, Iravani Fatemeh
出版信息
Acta Chim Slov. 2012 Sep;59(3):692-6.
PMID:24061328
Abstract
A one-pot isocyanide-based three-component reaction of 2-aminopyridine and acetylenic esters with alkyl isocyanides afforded tetraalkyl 4-(alkylamino)-2H-1,2'-bipyridine-2,3,5,6-tetracarboxylate and dialkyl 4-(alkylamino)-7-alkoxy-5-oxo-1-pyridin-2-yl-1,5-dihydrofuro[3,4-b]pyridine 2,3-dicarboxylate in good to high yields under mild reaction conditions.
摘要
在温和的反应条件下，2-氨基吡啶、炔酸酯与烷基异氰化物进行一锅法异氰化物基三组分反应，以良好至高产率得到四烷基4-(烷基氨基)-2H-1,2'-联吡啶-2,3,5,6-四羧酸酯和二烷基4-(烷基氨基)-7-烷氧基-5-氧代-1-吡啶-2-基-1,5-二氢呋喃并[3,4-b]吡啶2,3-二羧酸酯。
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