用于合成[2-(烷基硫烷基)咪唑并[1,2-a]吡啶-3-基](芳基)甲酮的新型一锅三组分反应。

Novel one-pot three component reaction for the synthesis of [2-(alkylsulfanyl)imidazo[1,2-a]pyridin-3-yl](aryl)methanone.

作者信息

Kianmehr Ebrahim, Ghanbari Mohammad, Niri Mehri Nadiri, Faramarzi Reza

机构信息

School of Chemistry, College of Science, University of Tehran, Tehran, Iran.

出版信息

J Comb Chem. 2010 Jan-Feb;12(1):41-4. doi: 10.1021/cc900103r.

DOI:10.1021/cc900103r

PMID:19904970

Abstract

A one-pot, three-component reaction between pyridine, phenacyl bromide, and thiocyanate is described. The reaction afforded the corresponding special type of fully substituted imidazo[1,2-a]pyridine derivatives in good yields without using any catalyst or activation.

摘要

本文描述了吡啶、苯甲酰溴和硫氰酸盐之间的一锅三组分反应。该反应无需使用任何催化剂或活化剂，就能以良好的产率得到相应特殊类型的全取代咪唑并[1,2-a]吡啶衍生物。