Institute of Human Genetics, Jena University Hospital, Friedrich Schiller University, Kollegiengasse 10, Postfach, 07743, Jena, Germany.
J Cancer Res Clin Oncol. 2013 Nov;139(11):1861-7. doi: 10.1007/s00432-013-1505-2. Epub 2013 Sep 6.
Liver metastases are the major cause of cancer-related death in colorectal cancer patients with a tendency to recur in over 50 % of the cases even after curatively intended surgery. Prognosis after liver resection, however, can neither be based on macroscopic or light microscopic evaluation of the metastases nor on clinical data alone. This is a pilot study in order to determine a potential influence of chromosomal aberrations on overall survival and relapse rate after curative liver resection.
Twenty randomly selected cases (10 patients with a survival of more and 10 patients with a survival of less than 5 years after resection) were studied by array comparative genomic hybridization.
The distributions concerning age, gender, stage and grading of primary tumor, percentage of patients with chemotherapy, number and distribution of the liver metastases, Nordlinger and Fong scores showed no differences between long- and short-term survivors and no correlation to any chromosomal aberration. However, the relapse rate of patients with (partial) monosomy 4 was lower and the long-time survival better than in the other patients.
Loss of chromosome 4 in colorectal liver metastases seems not only to be associated with the progression of the primary tumor as reported in the literature, but also with the long-term survival and the cumulative relapse rate after complete resection of colorectal liver metastases.
肝转移是结直肠癌患者癌症相关死亡的主要原因，即使在根治性手术之后，仍有超过 50%的病例倾向于复发。然而，肝切除术后的预后既不能基于转移灶的宏观或光镜评估，也不能仅基于临床数据。本研究旨在确定染色体畸变对结直肠癌肝转移患者根治性切除术后总生存率和复发率的潜在影响。
对 20 例随机选择的病例（10 例患者切除后生存时间超过 5 年，10 例患者切除后生存时间不足 5 年）进行了阵列比较基因组杂交分析。
长期和短期存活患者在年龄、性别、肿瘤分期和分级、化疗患者比例、肝转移灶数量和分布、Nordlinger 和 Fong 评分等方面的分布无差异，且与任何染色体畸变均无相关性。然而，存在（部分）单体 4 的患者的复发率较低，长期生存率较高。
结直肠肝转移中染色体 4 的缺失不仅与文献报道的原发性肿瘤的进展有关，而且与结直肠肝转移完全切除后的长期生存率和累积复发率有关。
