青少年糖尿病中的脂肪性肝炎和Ⅴ型高脂蛋白血症。病例报告及文献复习

Fatty liver hepatitis and type 5 hyperlipoproteinemia in juvenile diabetes mellitus. Case report and review of the literature.

作者信息

Lenaerts J, Verresen L, Van Steenbergen W, Fevery J

机构信息

Department of Medicine and Hepatology, University Hospital Gasthuisberg, Leuven, Belgium.

出版信息

J Clin Gastroenterol. 1990 Feb;12(1):93-7. doi: 10.1097/00004836-199002000-00024.

DOI:10.1097/00004836-199002000-00024

PMID:2406334

Abstract

A 28-year-old man with poorly controlled juvenile-onset diabetes mellitus presented with jaundice and type 5 hyperlipoproteinemia. A liver biopsy showed fatty liver hepatitis (steatonecrosis). This case represents one end in a spectrum of lipid disorders and liver disease in diabetes mellitus. With increasing insulin deficiency, liver steatosis and the more common type 4 hyperlipoproteinemia pattern may progress to fatty liver hepatitis and type 5 hyperlipoproteinemia.

摘要

一名28岁的青少年起病的糖尿病控制不佳的男性，出现黄疸和Ⅴ型高脂蛋白血症。肝脏活检显示为脂肪性肝炎（脂肪坏死）。该病例代表了糖尿病脂质紊乱和肝脏疾病谱中的一个极端情况。随着胰岛素缺乏加重，肝脂肪变性和更常见的Ⅳ型高脂蛋白血症模式可能进展为脂肪性肝炎和Ⅴ型高脂蛋白血症。