应用磁共振弹性成像技术评估慢性肝病儿童的肝纤维化。
Use of magnetic resonance elastography to assess hepatic fibrosis in children with chronic liver disease.
机构信息
Steatohepatitis Center, Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
出版信息
J Pediatr. 2014 Jan;164(1):186-8. doi: 10.1016/j.jpeds.2013.07.050. Epub 2013 Sep 21.
Abstract
Management of pediatric chronic liver disease is limited by lack of validated noninvasive biomarkers of histologic severity. We demonstrate that magnetic resonance elastography is feasible and accurate in detecting significant hepatic fibrosis in a case series of 35 children with chronic liver disease, including severely obese children.
摘要
小儿慢性肝病的管理受到缺乏经验证的组织学严重程度的非侵入性生物标志物的限制。我们证明磁共振弹性成像在 35 例慢性肝病儿童中检测显著肝纤维化是可行和准确的，包括严重肥胖的儿童。
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2
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3
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9
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