儿童骨肉瘤幸存者中的叶状肿瘤：单机构经验
Phyllodes tumor in survivors of childhood osteosarcoma: a single institution's experience.
作者信息
Jaing Tang-Her, Yang Chao-Ping, Hung Iou-Jih, Chen Shih-Hsiang, Tang Tzung-Chih, Shih Hsin-Nung, Hsueh Chuen
机构信息
*Department of Pediatrics, Division of Hematology/Oncology, Chang Gung Children's Hospital, Chang Gung University †Department of Internal Medicine, Division of Hematology/Oncology ‡Department of Orthopedic Surgery, Division of Joint Reconstruction §Department of Pathology, Chang Gung University, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
出版信息
J Pediatr Hematol Oncol. 2014 Jan;36(1):e36-8. doi: 10.1097/MPH.0b013e3182a6d4a4.
We evaluate the incidence of second neoplasms in 86 patients with osteosarcoma (OS) of the extremities treated with different protocols of adjuvant chemotherapy. Three patients developed phyllodes tumors as the second neoplasm. One of these patients simultaneously developed a third cancer with therapy-related acute myeloid leukemia. The sites of primary OS were the tibia (2) and humerus (1). None had received prior radiotherapy before excision of phyllodes tumor. All the patients were female with a median age of 21.7 years at the time of presentation. As yet, that precise causation is unclear, but it can increase our understanding of carcinogenic processes, in general.
我们评估了86例接受不同辅助化疗方案治疗的四肢骨肉瘤（OS）患者的第二肿瘤发生率。3例患者发生叶状肿瘤作为第二肿瘤。其中1例患者同时发生了与治疗相关的急性髓系白血病这第三种癌症。原发性骨肉瘤的部位为胫骨（2例）和肱骨（1例）。在叶状肿瘤切除前，所有患者均未接受过放疗。所有患者均为女性，就诊时中位年龄为21.7岁。目前，确切病因尚不清楚，但总体而言，这有助于我们加深对致癌过程的理解。
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