Ta Hang T, Dass Crispin R, Choong Peter F M, Dunstan Dave E
Department of Chemical and Biomolecular Engineering, University of Melbourne, Melbourne, VIC, 3010, Australia.
Cancer Metastasis Rev. 2009 Jun;28(1-2):247-63. doi: 10.1007/s10555-009-9186-7.
Osteosarcoma (OS) is a class of cancer originating from bone, mainly afflicting children or young adults. It is the second highest cause of cancer-related death in these age groups, mainly due to development of often fatal metastasis, usually in the lungs. Survival for these patients is poor despite the aggressive use of surgery, chemotherapy, and/or radiotherapy. Thus, new effective drugs and other forms of therapy are needed. This article reviews the biology and the state of the art management of OS. New experimental drugs and potential therapies targeting molecular pathways of OS are also discussed.
骨肉瘤（OS）是一类起源于骨骼的癌症，主要影响儿童或年轻人。它是这些年龄组中癌症相关死亡的第二大原因，主要是由于通常致命的转移灶的形成，通常转移至肺部。尽管积极采用手术、化疗和/或放疗，这些患者的生存率仍很低。因此，需要新的有效药物和其他治疗形式。本文综述了骨肉瘤的生物学特性及最新的治疗方法。还讨论了针对骨肉瘤分子途径的新型实验药物和潜在治疗方法。
