Ahmed Mahiuddin, Modak Shakeel, Sequeira Sonia
*Department of Pediatrics †Office of Clinical Research, Memorial Sloan-Kettering Cancer Center, New York, NY.
J Pediatr Hematol Oncol. 2014 Mar;36(2):152-5. doi: 10.1097/MPH.0000000000000024.
Nonpharmacologic, mind-body interventions are used to reduce anxiety in pediatric patients. Anti-ganglioside GD2 monoclonal antibody (anti-GD2 MoAb 3F8) therapy is the standard of care for high-risk neuroblastoma and pain is its major side effect. We performed a retrospective analysis of children undergoing anti-GD2 MoAb 3F8 treatment who received guided meditation. Meditation involved concentrating on the repetition of rhythmic, melodic sounds purported to slow breathing and induce a relaxation response. A total of 71% patients completed a session at first (n=19) or second attempt (n=5). Patients received fewer analgesic doses to manage anti-GD2 MoAb 3F8-induced pain when participating in meditation (n=17, mean=-0.4 dose, P<0.01). Mantram meditation is a feasible outpatient intervention associated with reduced analgesic requirements.
非药物性身心干预措施用于减轻儿科患者的焦虑。抗神经节苷脂GD2单克隆抗体（抗GD2 MoAb 3F8）疗法是高危神经母细胞瘤的标准治疗方法，疼痛是其主要副作用。我们对接受引导式冥想的接受抗GD2 MoAb 3F8治疗的儿童进行了回顾性分析。冥想包括专注于重复有节奏、旋律的声音，据说这些声音能减缓呼吸并引发放松反应。共有71%的患者在第一次（n = 19）或第二次尝试（n = 5）时完成了一次疗程。参与冥想时，患者用于控制抗GD2 MoAb 3F8引起的疼痛的镇痛药物剂量减少（n = 17，平均减少-0.4剂，P < 0.01）。曼陀罗冥想是一种可行的门诊干预措施，与减少镇痛需求相关。
