Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
J Ultrasound Med. 2013 Oct;32(10):1729-34. doi: 10.7863/ultra.32.10.1729.
The purpose of this study was to establish reference ranges for septum primum excursion and the septum primum excursion index.
Normal singleton pregnancies with certain dates from 14 to 40 weeks' gestation were enrolled to acquire spatiotemporal image correlation volume data sets. The stored data sets were subsequently displayed offline to measure septum primum excursion and the left atrium diameter. The measured values were regressed to identify the best-fitted model as a function of gestational age and biparietal diameter.
A total of 624 volumes were successfully measured, and normal reference ranges for predicting means and standard deviations of septum primum excursion and the septum primum excursion index were established based on best-fitted equations. The septum primum excursion index was relatively constant throughout pregnancy (mean ± SD, 0.474 ± 0.082), whereas septum primum excursion increased with gestational age and biparietal diameter as follows: (1) septum primum excursion = -6.30 + 0.667 × gestational age - 0.009 × gestational age(2); SD of septum primum excursion = 0.219 + 0.02 × gestational age; and (2) septum primum excursion = -3.342 + 1.933 × biparietal diameter - 0.102 × biparietal diameter(2); SD of septum primum excursion = 0.330 + 0.065 × biparietal diameter. Percentile charts for predicting septum primum excursion and equations for Z score calculation were also provided.
Normal reference ranges for fetal septum primum excursion and the septum primum excursion index have been provided. These normative data may be useful tools for assessment of hemodynamics through the foramen ovale or left ventricular diastolic function.
本研究旨在建立卵圆孔未闭和卵圆孔未闭指数的隔瓣活动度参考范围。
纳入了一定孕周（14 至 40 周）的正常单胎妊娠孕妇，以获取时空关联成像容积数据集。随后离线显示存储的数据集，以测量隔瓣活动度和左心房直径。将测量值回归以确定最佳拟合模型作为胎龄和双顶径的函数。
共成功测量了 624 个容积，根据最佳拟合方程建立了预测卵圆孔未闭和卵圆孔未闭指数均值和标准差的正常参考范围。卵圆孔未闭指数在整个孕期相对恒定（均值±标准差，0.474±0.082），而隔瓣活动度随胎龄和双顶径的增加而增加，具体为：（1）隔瓣活动度=-6.30+0.667×胎龄-0.009×胎龄²；隔瓣活动度标准差=0.219+0.02×胎龄；（2）隔瓣活动度=-3.342+1.933×双顶径-0.102×双顶径²；隔瓣活动度标准差=0.330+0.065×双顶径。还提供了预测隔瓣活动度的百分位数图表和 Z 评分计算方程。
提供了胎儿隔瓣活动度和隔瓣活动度指数的正常参考范围。这些正常数据可能是评估卵圆孔未闭或左心室舒张功能的血流动力学的有用工具。
