Wei L, Gao Y J, Wei S P, Zhang Y F, Zhang W F, Jiang J X, Sun Z Y, Xu W
Department of Neurosurgery, East Hospital, Tongji University School of Medicine, Shanghai, China.
Genet Mol Res. 2013 Sep 3;12(3):3263-73. doi: 10.4238/2013.September.3.2.
Intracranial aneurysm is a balloon or sac-like dilatation of blood vessels inside the brain. Despite their importance, the biological mechanisms of intracranial aneurysms are not totally understood. We used public genome-wide gene expression profile data to identify potential genes that are involved in intracranial aneurysm in order to construct a regulation network. Some of the transcription factors and target genes that we identified in this network had been identified as related to intracranial aneurysm in previous studies. We found additional transcription factors and target genes that are apparently related to intracranial aneurysm with this method. The confirmation of previously identified genes and transcription factors supports the usefulness of this transcriptome network analysis for the identification of candidate genes involved in intracranial aneurysm.
颅内动脉瘤是脑内血管呈气球样或囊状扩张。尽管其很重要，但颅内动脉瘤的生物学机制尚未完全明确。我们利用公开的全基因组基因表达谱数据来识别参与颅内动脉瘤形成的潜在基因，以构建调控网络。我们在这个网络中识别出的一些转录因子和靶基因在先前的研究中已被确定与颅内动脉瘤相关。通过这种方法，我们发现了其他一些明显与颅内动脉瘤相关的转录因子和靶基因。对先前已识别基因和转录因子的验证支持了这种转录组网络分析在识别参与颅内动脉瘤形成的候选基因方面的实用性。
