Vijayan Tara, Klausner Jeffrey D
Division of Infectious Diseases, University of California, San Francisco, CA, USA.
J Int Assoc Provid AIDS Care. 2013 Sep-Oct;12(5):301-5. doi: 10.1177/2325957413500472.
The success of antiretroviral therapy (ART) programs in the developing world is limited by the lack of adequate diagnostic tests to screen for life-threatening opportunistic infections such as tuberculosis (TB) and cryptococcal disease. Furthermore, there is an increasing need for implementation research in measuring the effectiveness of currently available rapid diagnostic tests. The recently developed lateral flow assays for both cryptococcal disease and TB have the potential to improve care and greatly reduce the time to initiation of ART among individuals who need it the most. However, we caution that the data on feasibility and effectiveness of these assays are limited and such research agendas must be prioritized.
发展中世界抗逆转录病毒疗法（ART）项目的成功受到限制，因为缺乏足够的诊断测试来筛查如结核病（TB）和隐球菌病等危及生命的机会性感染。此外，在衡量现有快速诊断测试的有效性方面，实施研究的需求日益增加。最近开发的用于隐球菌病和结核病的侧向流动检测法有潜力改善医疗护理，并大幅缩短最需要抗逆转录病毒疗法的个体开始治疗的时间。然而，我们提醒，这些检测法的可行性和有效性数据有限，此类研究议程必须予以优先考虑。
