在发展中世界整合针对艾滋病毒、结核病和隐球菌病的临床服务：两项新型诊断测试向前迈出的一步。
Integrating clinical services for HIV, tuberculosis, and cryptococcal disease in the developing world: a step forward with 2 novel diagnostic tests.
作者信息
Vijayan Tara, Klausner Jeffrey D
机构信息
Division of Infectious Diseases, University of California, San Francisco, CA, USA.
出版信息
J Int Assoc Provid AIDS Care. 2013 Sep-Oct;12(5):301-5. doi: 10.1177/2325957413500472.
Abstract
The success of antiretroviral therapy (ART) programs in the developing world is limited by the lack of adequate diagnostic tests to screen for life-threatening opportunistic infections such as tuberculosis (TB) and cryptococcal disease. Furthermore, there is an increasing need for implementation research in measuring the effectiveness of currently available rapid diagnostic tests. The recently developed lateral flow assays for both cryptococcal disease and TB have the potential to improve care and greatly reduce the time to initiation of ART among individuals who need it the most. However, we caution that the data on feasibility and effectiveness of these assays are limited and such research agendas must be prioritized.
摘要
发展中世界抗逆转录病毒疗法（ART）项目的成功受到限制，因为缺乏足够的诊断测试来筛查如结核病（TB）和隐球菌病等危及生命的机会性感染。此外，在衡量现有快速诊断测试的有效性方面，实施研究的需求日益增加。最近开发的用于隐球菌病和结核病的侧向流动检测法有潜力改善医疗护理，并大幅缩短最需要抗逆转录病毒疗法的个体开始治疗的时间。然而，我们提醒，这些检测法的可行性和有效性数据有限，此类研究议程必须予以优先考虑。
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本文引用的文献
1
Urine antigen test for diagnosis of HIV-associated tuberculosis.用于诊断HIV相关结核病的尿液抗原检测
Lancet Infect Dis. 2012 Nov;12(11):825; author reply 826-7. doi: 10.1016/S1473-3099(12)70220-7.
2
Cryptococcal antigen screening and preemptive therapy in patients initiating antiretroviral therapy in resource-limited settings: a proposed algorithm for clinical implementation.资源有限环境下启动抗逆转录病毒治疗患者的隐球菌抗原筛查及抢先治疗：一项临床实施的拟议算法
J Int Assoc Physicians AIDS Care (Chic). 2012 Nov-Dec;11(6):374-9. doi: 10.1177/1545109712459077. Epub 2012 Sep 26.
3
The ethics of testing a test: randomized trials of the health impact of diagnostic tests for infectious diseases.检测的伦理：随机试验检测传染病诊断试验对健康的影响。
Clin Infect Dis. 2012 Dec;55(11):1522-6. doi: 10.1093/cid/cis736. Epub 2012 Aug 23.
4
Challenges facing lipoarabinomannan urine antigen tests for diagnosing HIV-associated tuberculosis.用于诊断HIV相关结核病的脂阿拉伯甘露聚糖尿液抗原检测面临的挑战。
Expert Rev Mol Diagn. 2012 Jul;12(6):549-51. doi: 10.1586/erm.12.52.
5
Clinical significance of lipoarabinomannan detection in urine using a low-cost point-of-care diagnostic assay for HIV-associated tuberculosis.使用低成本即时诊断检测方法检测尿液中脂阿拉伯甘露聚糖对 HIV 相关结核病的临床意义。
AIDS. 2012 Aug 24;26(13):1635-43. doi: 10.1097/QAD.0b013e3283553685.
6
Point-of-care detection of lipoarabinomannan (LAM) in urine for diagnosis of HIV-associated tuberculosis: a state of the art review.即时检测尿液中的脂阿拉伯甘露聚糖 (LAM) 用于诊断 HIV 相关结核病：一项技术综述。
BMC Infect Dis. 2012 Apr 26;12:103. doi: 10.1186/1471-2334-12-103.
7
Integrating cryptococcal antigen screening and pre-emptive treatment into routine HIV care.将隐球菌抗原筛查和预防性治疗纳入常规 HIV 护理中。
J Acquir Immune Defic Syndr. 2012 Apr 15;59(5):e85-91. doi: 10.1097/QAI.0b013e31824c837e.
8
Early mortality in adults initiating antiretroviral therapy (ART) in low- and middle-income countries (LMIC): a systematic review and meta-analysis.成人在中低收入国家（LMIC）开始抗逆转录病毒疗法（ART）的早期死亡率：系统评价和荟萃分析。
PLoS One. 2011;6(12):e28691. doi: 10.1371/journal.pone.0028691. Epub 2011 Dec 29.
9
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Clin Infect Dis. 2012 Mar 1;54(5):739-40. doi: 10.1093/cid/cir908. Epub 2011 Dec 21.
10
Costs and efficiency of integrating HIV/AIDS services with other health services: a systematic review of evidence and experience.将艾滋病病毒/艾滋病服务与其他卫生服务相结合的成本和效率：证据和经验的系统评价。
Sex Transm Infect. 2012 Mar;88(2):85-99. doi: 10.1136/sextrans-2011-050199. Epub 2011 Dec 8.
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