Fraga M, Doerig C, Dorta G, Nichita C
Service de gastroentérologie et d'hépatologie, CHUV et Université de Lausanne, 1011 Lausanne.
Rev Med Suisse. 2013 Sep 4;9(396):1572-6.
Barrett's esophagus consists of the replacement of normal squamous epithelium by a specialised columnar lined epithelium referred to as intestinal metaplasia in the esophagus. It represents a premalignant lesion. The prevalence of Barrett's esophagus is around 1.6%. Esophageal adenocarcinoma results from the development of dysplasia progressing from low to high grade dysplasia and finally adenocarcinoma. Radiofrequency ablation currently represents the treatment of choice in eradicating Barrett's esophagus with associated dysplasia. The technique is based on the application of a radiofrequency current that enables the destruction of the superficial modified epithelium. This new approach presents a good security profile and, compared to other ablative techniques, shows superior results regarding Barrett's eradication.
巴雷特食管是指食管内正常鳞状上皮被一种特殊的柱状上皮所取代，这种柱状上皮被称为食管肠化生。它是一种癌前病变。巴雷特食管的患病率约为1.6%。食管腺癌是由发育异常从低级别发育异常进展为高级别发育异常，最终发展为腺癌而导致的。目前，射频消融是根除伴有发育异常的巴雷特食管的首选治疗方法。该技术基于射频电流的应用，能够破坏浅表的化生上皮。这种新方法具有良好的安全性，与其他消融技术相比，在根除巴雷特食管方面显示出更好的效果。
