Godat S, Velin D, Aubert V, Nydegger A, Schoepfer A M, Maillard M H
Service de gastroentérologie et d'hépatologie, CHUV, 1011 Lausanne.
Rev Med Suisse. 2013 Sep 4;9(396):1584-9.
Celiac disease is a well-known entity in pediatrics and pediatric gastroenterology that is now also frequently encountered in the adult population. Apart from typical symptoms, celiac disease can present with a wide range of manifestations that are sometimes atypical, scarce or purely extraintestinal. Serologic and genetic testing are useful tools in case of low clinical probability in the early diagnostic algorithm. Upper gastrointestinal endoscopy remains the mainstay to confirm the diagnosis especially in atypical clinical presentations. Complications are rare but can be severe. Although gluten-free diet often leads to complete recovery, compliance is not universal and alternative treatment strategies are under investigation.
乳糜泻在儿科学和儿科胃肠病学领域是一个广为人知的病症，如今在成人中也日益常见。除了典型症状外，乳糜泻还可能表现出各种各样的症状，有时是非典型的、罕见的或纯粹是肠外的。在早期诊断流程中，当临床可能性较低时，血清学和基因检测是有用的工具。上消化道内镜检查仍然是确诊的主要手段，尤其是在非典型临床表现的情况下。并发症很少见，但可能很严重。尽管无麸质饮食通常会带来完全康复，但依从性并不普遍，替代治疗策略正在研究中。
