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The effects of selective dopamine D-1 and D-2 antagonists on the locomotor response and brain monoamine changes induced by naloxone-precipitated morphine withdrawal in guinea pigs.

作者信息

Brent P J, Chahl L A

机构信息

Neuropharmacology Laboratory, Faculty of Medicine, University of Newcastle, New South Wales, Australia.

出版信息

Prog Clin Biol Res. 1990;328:515-8.

PMID:2406762
Abstract
摘要

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The effects of selective dopamine D-1 and D-2 antagonists on the locomotor response and brain monoamine changes induced by naloxone-precipitated morphine withdrawal in guinea pigs.选择性多巴胺D-1和D-2拮抗剂对豚鼠纳洛酮诱发的吗啡戒断所致运动反应及脑单胺变化的影响。
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Total neurochemical lesion of noradrenergic neurons of the locus ceruleus does not alter either naloxone-precipitated or spontaneous opiate withdrawal nor does it influence ability of clonidine to reverse opiate withdrawal.蓝斑去甲肾上腺素能神经元的完全神经化学损伤既不会改变纳洛酮诱发的或自发的阿片戒断反应，也不会影响可乐定逆转阿片戒断反应的能力。
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引用本文的文献

1
Behavioural effects of selective dopamine D-1 and D-2 agonists and antagonists in guinea-pigs.选择性多巴胺D-1和D-2激动剂与拮抗剂对豚鼠的行为影响。
Psychopharmacology (Berl). 1991;104(2):201-7. doi: 10.1007/BF02244179.
2
Effects of naloxone-precipitated withdrawal after a single dose of morphine on catecholamine concentrations in guinea-pig brain.单次注射吗啡后纳洛酮诱发的戒断反应对豚鼠脑内儿茶酚胺浓度的影响。
Neurochem Res. 1991 May;16(5):525-31. doi: 10.1007/BF00974870.
3
Tachykinin antagonists inhibit the morphine withdrawal response in guinea-pigs.
Naunyn Schmiedebergs Arch Pharmacol. 1991 Mar;343(3):283-8. doi: 10.1007/BF00251127.
4
Similar behavioural effects of sigma agonists and PCP-like non-competitive NMDA antagonists in guinea-pigs.
Psychopharmacology (Berl). 1991;105(3):421-7. doi: 10.1007/BF02244439.
5
Morphine, D-Pen2, D-Pen5 enkephalin and U50,488H differentially affect the locomotor activity and behaviours induced by quinpirole in guinea-pigs.吗啡、D-青霉胺2、D-青霉胺5脑啡肽和U50,488H对豚鼠中由喹吡罗诱导的运动活动和行为有不同影响。
Psychopharmacology (Berl). 1992;107(4):581-90. doi: 10.1007/BF02245274.