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SKN-1/Nrf, a new unfolded protein response factor?

作者信息

Choe Keith P, Leung Chi K

机构信息

Department of Biology and Genetics Institute, University of Florida, Gainesville, Florida, United States of America.

出版信息

PLoS Genet. 2013;9(9):e1003827. doi: 10.1371/journal.pgen.1003827. Epub 2013 Sep 12.

DOI:10.1371/journal.pgen.1003827
PMID:24068977
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3772053/
Abstract
摘要

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本文引用的文献

1
Integration of the unfolded protein and oxidative stress responses through SKN-1/Nrf.通过 SKN-1/Nrf 实现未折叠蛋白和氧化应激反应的整合。
PLoS Genet. 2013;9(9):e1003701. doi: 10.1371/journal.pgen.1003701. Epub 2013 Sep 12.
2
Nuclear factor-erythroid 2-related factor 1 regulates expression of proteasome genes in hepatocytes and protects against endoplasmic reticulum stress and steatosis in mice.核因子-红细胞 2 相关因子 1 调节肝细胞中蛋白酶体基因的表达，并可防止内质网应激和小鼠脂肪变性。
FEBS J. 2013 Aug;280(15):3609-20. doi: 10.1111/febs.12350. Epub 2013 Jun 18.
3
An involvement of oxidative stress in endoplasmic reticulum stress and its associated diseases.
表皮生长因子（EGF）信号通路对谷胱甘肽S-转移酶4（GST-4）的不依赖SKN-1的转录激活作用
Worm. 2016 Aug 31;5(4):e1230585. doi: 10.1080/21624054.2016.1230585. eCollection 2016.
氧化应激在内质网应激及其相关疾病中的作用。
Int J Mol Sci. 2012 Dec 24;14(1):434-56. doi: 10.3390/ijms14010434.
4
TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO.TOR 信号通路和雷帕霉素通过调控 SKN-1/Nrf 和 DAF-16/FoxO 影响寿命。
Cell Metab. 2012 May 2;15(5):713-24. doi: 10.1016/j.cmet.2012.04.007.
5
Redox signaling loops in the unfolded protein response.未折叠蛋白反应中的氧化还原信号环。
Cell Signal. 2012 Aug;24(8):1548-55. doi: 10.1016/j.cellsig.2012.03.011. Epub 2012 Mar 28.
6
Depletion of a nucleolar protein activates xenobiotic detoxification genes in Caenorhabditis elegans via Nrf /SKN-1 and p53/CEP-1.通过 Nrf/SKN-1 和 p53/CEP-1，核仁蛋白的耗竭可激活秀丽隐杆线虫中的外来化合物解毒基因。
Free Radic Biol Med. 2012 Mar 1;52(5):937-50. doi: 10.1016/j.freeradbiomed.2011.12.009. Epub 2011 Dec 23.
7
Specific SKN-1/Nrf stress responses to perturbations in translation elongation and proteasome activity.特定的 SKN-1/Nrf 应激反应对翻译延伸和蛋白酶体活性的干扰。
PLoS Genet. 2011 Jun;7(6):e1002119. doi: 10.1371/journal.pgen.1002119. Epub 2011 Jun 9.
8
RNAi screening implicates a SKN-1-dependent transcriptional response in stress resistance and longevity deriving from translation inhibition.RNAi 筛选表明，翻译抑制导致的应激抵抗和寿命延长与 SKN-1 依赖的转录反应有关。
PLoS Genet. 2010 Aug 5;6(8):e1001048. doi: 10.1371/journal.pgen.1001048.
9
Stress-activated cap'n'collar transcription factors in aging and human disease.应激激活的帽结合转录因子在衰老和人类疾病中的作用。
Sci Signal. 2010 Mar 9;3(112):re3. doi: 10.1126/scisignal.3112re3.
10
The Nrf3 transcription factor is a membrane-bound glycoprotein targeted to the endoplasmic reticulum through its N-terminal homology box 1 sequence.Nrf3转录因子是一种膜结合糖蛋白，通过其N端同源框1序列定位于内质网。
J Biol Chem. 2009 Jan 30;284(5):3195-3210. doi: 10.1074/jbc.M805337200. Epub 2008 Dec 1.