Fink Marc Y, Chipuk Jerry E
Department of Biomedical Sciences, Long Island University Post, Brookville, NY, USA.
Genes Cancer. 2013 May;4(5-6):187-95. doi: 10.1177/1947601913488598.
HER2 is overexpressed in a subset of breast cancers and controls an oncogenic signaling network that inhibits tumor cell death through the specific biochemical regulation of apoptotic pathways. In particular, the mitochondrial pathway for apoptosis is important for death induced by inhibitors of HER2. This review focuses on the connections between this oncogenic signaling network and individual components of the mitochondrial pathway. A comprehensive view of this signaling network is crucial for developing novel drugs in this area and to gain an understanding of how these regulatory interactions are altered in drug-refractory cancers.
HER2在一部分乳腺癌中过度表达，并控制着一个致癌信号网络，该网络通过对凋亡途径的特定生化调节来抑制肿瘤细胞死亡。特别是，凋亡的线粒体途径对于HER2抑制剂诱导的细胞死亡很重要。本综述聚焦于这个致癌信号网络与线粒体途径各个组分之间的联系。全面了解这个信号网络对于开发该领域的新药以及理解这些调节相互作用在耐药性癌症中是如何改变的至关重要。
