The Transplant Institute, Sahlgrenska University Hospital, Gothenburg 41345, Sweden.
J Transl Med. 2013 Sep 26;11:233. doi: 10.1186/1479-5876-11-233.
Resistin increases during several inflammatory diseases and after intracerebral bleeding or head trauma. Resistin activates the endothelium and may initiate an inflammatory response. No data are available on resistin in brain dead donors (DBD) that regularly manifest a pronounced inflammatory state.
We analyzed plasma resistin in 63 DBDs and correlated results with donor variables and the postoperative course following kidney transplantation using organs from these donors. Endocan and monocyte chemotactic protein (MCP)-1 were also studied. Twenty-six live kidney donors (LD) and the corresponding kidney transplantations were used as controls.
DBDs had higher resistin (median/range 30.75 ng/ml, 5.41-173.6) than LD (7.71 ng/ml, 2.41-15.74, p < 0.0001). Resistin in DBD correlated with delayed graft function (DGF) in the kidney recipients (r = 0.321, p < 0.01); receiver operating characteristic curve revealed an area under the curve of 0.765 (95% confidence interval [CI] 0.648-0.881, p < 0.01) and a cut-off value for resistin of 25 ng/ml; MCP-1 and endocan were higher in DBDs (p < 0.0001) but did not correlate with DGF or acute rejection. No relationship was found between the studied molecules and the postoperative course of LD kidney transplants.
High resistin levels in the DBD before organ retrieval are associated with DGF after kidney transplantation. The resistin increase seems related to the inflammatory state after brain death but not to the cause of death.
抵抗素在几种炎症性疾病以及脑出血或颅脑创伤后会增加。抵抗素可激活内皮细胞并引发炎症反应。目前尚无脑死亡供者（DBD）中抵抗素的数据，而这些供者通常表现出明显的炎症状态。
我们分析了 63 例 DBD 的血浆抵抗素，并将结果与供者变量以及这些供者的器官肾移植后的术后过程相关联。同时还研究了内皮脂素和单核细胞趋化蛋白-1（MCP-1）。26 例活体供肾者（LD）及其相应的肾移植被用作对照。
DBD 的抵抗素（中位数/范围 30.75ng/ml，5.41-173.6）高于 LD（7.71ng/ml，2.41-15.74，p<0.0001）。DBD 的抵抗素与肾移植受者的延迟移植物功能（DGF）相关（r=0.321，p<0.01）；ROC 曲线显示曲线下面积为 0.765（95%置信区间[CI]0.648-0.881，p<0.01），抵抗素的截断值为 25ng/ml；DBD 中的 MCP-1 和内皮脂素水平更高（p<0.0001），但与 DGF 或急性排斥无关。在 LD 肾移植的术后过程中，未发现研究分子之间存在任何关系。
器官采集前 DBD 中的高抵抗素水平与肾移植后 DGF 相关。抵抗素的增加似乎与脑死亡后的炎症状态有关，但与死亡原因无关。
