First Department of Internal Medicine, Nara Medical University, Nara, Japan.
J Cardiovasc Magn Reson. 2013 Sep 26;15(1):87. doi: 10.1186/1532-429X-15-87.
Evaluation of left ventricular (LV) diastolic function is essential for the management of heart failure. We verified whether LV diastolic function could be evaluated by measuring the fractional area change (FAC) using cine cardiovascular magnetic resonance (CMR).
We collected clinical data from 59 patients who underwent echocardiography and cine CMR. Normal, impaired relaxation, pseudonormal, and restrictive LV filling were observed in 15, 28, 11, and 5 patients, respectively. We calculated FAC during the first 30% of diastole (diastolic-index%) in the short-axis view, by tracing the contours on only three MR cine images.
The diastolic index was significantly lower (p < 0.0001) in patients with impaired relaxation (32.4 ± 7.5), pseudonormal filling (25.4 ± 5.6), and restrictive filling (9.5 ± 1.5) compared to those with normal diastolic function (67.7 ± 10.8), and the index decreased significantly with worsening of diastolic dysfunction. The diastolic index correlated positively with early diastolic mitral annular velocity measured by tissue Doppler imaging (r = 0.75, p < 0.0001), respectively.
Measurement of FAC can be useful for the evaluation of LV diastolic function using cine CMR.
评估左心室（LV）舒张功能对于心力衰竭的管理至关重要。我们通过测量电影心血管磁共振（CMR）的分数面积变化（FAC）来验证是否可以评估 LV 舒张功能。
我们收集了 59 例接受超声心动图和电影 CMR 的患者的临床数据。在 15 例、28 例、11 例和 5 例患者中分别观察到正常、松弛不良、假性正常和限制性 LV 充盈。我们通过仅追踪三个 MR 电影图像上的轮廓，计算短轴视图中舒张期前 30%（舒张指数%）的 FAC。
与舒张功能正常的患者（67.7 ± 10.8）相比，松弛不良（32.4 ± 7.5）、假性正常充盈（25.4 ± 5.6）和限制性充盈（9.5 ± 1.5）患者的舒张指数显著降低（p < 0.0001），舒张功能障碍程度越严重，舒张指数越低。舒张指数与组织多普勒成像测量的早期舒张二尖瓣环速度呈正相关（r = 0.75，p < 0.0001）。
使用电影 CMR 测量 FAC 可用于评估 LV 舒张功能。
