Department of Surgical Oncology, Montpellier Cancer Institute (ICM), 34298 Montpellier, France.
Departement of Medical Oncology, Montpellier Cancer Institute (ICM), 34298 Montpellier, France.
Crit Rev Oncol Hematol. 2014 Feb;89(2):207-16. doi: 10.1016/j.critrevonc.2013.08.017. Epub 2013 Sep 8.
Ovarian carcinoma is the most lethal gynaecologic malignancy. Despite wide initial sensibility to chemotherapy especially to platinum-based regimens, the vast majority of patients with advanced stages of the disease develop recurrences and subsequent resistance to treatments. Ovarian cancer is actually considered as a heterogeneous disease at the clinical, histological and molecular level. In this review, the mechanisms of intrinsic sensitivity or resistance to treatment, especially to platinum-based chemotherapy are considered with particular reference to the significance of tumour heterogeneity. The molecular features involved in acquired resistance are reviewed and the current hypotheses are discussed. In particular, potential disruptions of the DNA reparation pathways are highlighted.
卵巢癌是妇科恶性肿瘤中最致命的一种。尽管大多数晚期患者对化疗，特别是铂类药物方案最初具有广泛的敏感性，但绝大多数患者都会出现复发，并随后对治疗产生耐药性。实际上，卵巢癌在临床、组织学和分子水平上被认为是一种异质性疾病。在这篇综述中，考虑了内在治疗敏感性或耐药性的机制，特别是针对铂类化疗的机制，并特别参考了肿瘤异质性的意义。还回顾了获得性耐药相关的分子特征，并讨论了当前的假设。特别是，强调了 DNA 修复途径的潜在破坏。
