结核分枝杆菌耐药性的复杂遗传学。
Complex genetics of drug resistance in Mycobacterium tuberculosis.
机构信息
Medical Research Council (MRC)-National Health Laboratory Service (NHLS)-University of Cape Town Molecular Mycobacteriology Research Unit and Department of Science and Technology (DST)-National Research Foundation (NRF) Centre of Excellence for Biomedical Tuberculosis Research, Institute of Infectious Disease and Molecular Medicine, and the Department of Clinical Laboratory Sciences, Faculty of Health Sciences, University of Cape Town, Rondebosch, South Africa.
出版信息
Nat Genet. 2013 Oct;45(10):1107-8. doi: 10.1038/ng.2769.
Three new studies have used whole-genome sequencing of M. tuberculosis to demonstrate unexpected complexity in the modern evolution of drug-resistant tuberculosis, and a fourth study suggests a close evolutionary relationship between the pathogen and its human host over a period of 70,000 years. Collectively, the observations in these studies suggest that future strategies to tackle drug-resistant tuberculosis must integrate host genetics with detailed strain epidemiology.
三项新研究利用结核分枝杆菌全基因组测序，展示了耐药结核分枝杆菌在现代进化过程中的出人意料的复杂性，第四项研究则表明，在 7 万年的时间里，病原体与其人类宿主之间存在密切的进化关系。这些研究的观察结果表明，未来解决耐药结核分枝杆菌问题的策略必须将宿主遗传学与详细的菌株流行病学相结合。
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