Kim Jong Hyun, Han Jung Min, Kim Sunghoon
Medicinal Bioconvergence Research Center, Graduate School of Convergence Science and Technology, College of Pharmacy, Seoul National University, Seoul, 151-742, South Korea,
Top Curr Chem. 2014;344:119-44. doi: 10.1007/128_2013_479.
Protein-protein interaction occurs transiently or stably when two or more proteins bind together to mediate a wide range of cellular processes such as protein modification, signal transduction, protein trafficking, and structural folding. The macromolecules involved in protein biosynthesis such as aminoacyl-tRNA synthetase (ARS) have a number of protein-protein interactions. The mammalian multi-tRNA synthetase complex (MSC) consists of eight different enzymes: EPRS, IRS, LRS, QRS, MRS, KRS, RRS, and DRS, and three auxiliary proteins: AIMP1/p43, AIMP2/p38, and AIMP/p18. The distinct ARS proteins are also connected to diverse protein networks to carry out biological functions. In this chapter we first show the protein networks of the entire MSC and explain how MSC components interact with or can regulate other proteins. Finally, it is pointed out that the understanding of protein-protein interaction mechanism will provide insight to potential therapeutic application for diseases related to the MSC network.
当两个或更多蛋白质结合在一起以介导广泛的细胞过程（如蛋白质修饰、信号转导、蛋白质运输和结构折叠）时，蛋白质-蛋白质相互作用会瞬时或稳定地发生。参与蛋白质生物合成的大分子，如氨酰-tRNA合成酶（ARS），存在多种蛋白质-蛋白质相互作用。哺乳动物多tRNA合成酶复合体（MSC）由八种不同的酶组成：EPRS、IRS、LRS、QRS、MRS、KRS、RRS和DRS，以及三种辅助蛋白：AIMP1/p43、AIMP2/p38和AIMP/p18。不同的ARS蛋白也连接到不同的蛋白质网络以执行生物学功能。在本章中，我们首先展示整个MSC的蛋白质网络，并解释MSC组件如何与其他蛋白质相互作用或调节其他蛋白质。最后指出，对蛋白质-蛋白质相互作用机制的理解将为与MSC网络相关疾病的潜在治疗应用提供见解。
