索特诺尔对血管及其他平滑肌具有强效的α-肾上腺素能受体作用。
Potent alpha-adrenoceptor action of soterenol on vascular and other smooth muscle.
作者信息
Kitagawa H, Yamauchi A, Shibata S
出版信息
Eur J Pharmacol. 1975 Aug;33(1):227-30. doi: 10.1016/0014-2999(75)90163-6.
PMID:240730
Abstract
Treatment with soterenol (0.3-300 mug/kg, i.v.) increased the mean arterial blood pressure and decreased heart rate in rabbits. Soterenol caused a dose-dependent contraction of rabbit aorta and portal vein, guinea-pig vas deferens and cat nicitating membrane which was inhibited by phentolamine. Other beta-agonists such as isoproterenol, salbutamol and terbutaline did not exhibit similar effects. Soterenol had potent stimulant action on the alpha-receptor of the smooth muscle.
摘要
索特雷诺（0.3 - 300微克/千克，静脉注射）治疗可使家兔平均动脉血压升高，并使心率降低。索特雷诺可引起家兔主动脉和门静脉、豚鼠输精管以及猫瞬膜剂量依赖性收缩，酚妥拉明可抑制这种收缩。其他β - 激动剂如异丙肾上腺素、沙丁胺醇和特布他林未表现出类似作用。索特雷诺对平滑肌的α受体有强效刺激作用。
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