Social and Behavioral Research Branch, National Human Genome Research Institute, National Institutes of Health, Building 31, Room B1B54, 31 Center Drive, Bethesda, MD 20892 USA ; Annenberg School for Communication, University of Pennsylvania, Philadelphia, PA USA.
Transl Behav Med. 2012 Dec;2(4):392-400. doi: 10.1007/s13142-012-0159-y.
Varying perspectives exist regarding the implications of genetic susceptibility testing for common disease, with some anticipating adverse effects and others expecting positive outcomes; however, little is known about the characteristics of people who are most likely to be interested in direct-to-consumer genetic testing. To that end, this study examines the association of individual dispositional differences with health risk perceptions and online information seeking related to a free genetic susceptibility test. Healthy adults enrolled in a large health maintenance organization were surveyed by telephone. Eligible participants (N = 1,959) were given access to a secure website that provided risk and benefit information about a genetic susceptibility test and given the option to be tested. Neuroticism was associated with increased perceptions of disease risk but not with logging on. Those scoring high in conscientiousness were more likely to log on. We found no evidence that neuroticism, a dispositional characteristic commonly linked to adverse emotional response, was predictive of online genetic information seeking in this sample of healthy adults.
关于遗传易感性检测对常见疾病的影响存在不同的观点，一些人预计会有不利影响，而另一些人则期望有积极的结果；然而，对于最有可能对直接面向消费者的基因检测感兴趣的人的特征，我们知之甚少。为此，本研究考察了个体特质差异与健康风险感知的关系，以及与免费遗传易感性检测相关的在线信息搜索。通过电话对参加大型健康维护组织的健康成年人进行了调查。符合条件的参与者（N=1959）被允许访问一个安全的网站，该网站提供了遗传易感性检测的风险和收益信息，并提供了检测的选项。神经质与疾病风险感知的增加有关，但与登录无关。那些责任心得分高的人更有可能登录。我们没有发现神经质（一种与不良情绪反应常有关联的性格特征）在这个健康成年人样本中是在线遗传信息搜索的预测因素。
