Rossini Daniele, Caponnetto Salvatore, Lapadula Vittoria, De Filippis Lucilla, Del Bene Gabriella, Emiliani Alessandra, Longo Flavia
Department of Clinical Oncology A, Sapienza University of Rome, Policlinico Umberto Primo, Viale Regina Elena 324, 00161 Rome, Italy.
Case Rep Oncol Med. 2013;2013:131695. doi: 10.1155/2013/131695. Epub 2013 Sep 1.
Merkel cell carcinoma (MCC) is an extremely rare primary neuroendocrine neoplasm of the skin that shows aggressive behavior and a poor prognosis. We report a case of a 67-year-old male with a Merkel cell carcinoma which initially presented itself as a large retroperitoneal mass. Pathological and immunohistochemical analysis revealed tissue consistent with neuroendocrine carcinoma. Despite complete medical workup, no other primary MCC could be detected. While being an atypical presentation, the tumor mass showed an excellent response to the combination of chemotherapy followed by radiotherapy.
默克尔细胞癌（MCC）是一种极其罕见的原发性皮肤神经内分泌肿瘤，具有侵袭性且预后较差。我们报告一例67岁男性默克尔细胞癌病例，该病例最初表现为巨大的腹膜后肿块。病理及免疫组化分析显示组织符合神经内分泌癌。尽管进行了全面的医学检查，但未发现其他原发性默克尔细胞癌。虽然这是一种非典型表现，但肿瘤肿块对化疗联合放疗的治疗方案反应良好。
