Somaweera Himali, Lai Gary C, Blackeye Rachel, Littlejohn Beverly, Kirksey Justine, Aguirre Richard M, Lapena Vince, Pasqua Anna, Hintz Mary McCarthy
Department of Chemistry, California State University, Sacramento, California, USA.
J Herb Med. 2013 Jun 1;3(2):47-51. doi: 10.1016/j.hermed.2013.01.001.
California mugwort ( Besser) is used by many tribes throughout California to treat a variety of conditions, including colds, allergies, and pain. California mugwort is also utilized as women's medicine. Its use is on the rise outside of Native communities, often without the guidance of a traditional healer or experienced herbalist. Because it has been shown to have antiproliferative activity against plant and animal cells, we investigated whether California mugwort extracts have an effect on normal human cells as well as estrogen receptor positive (ER) and estrogen receptor negative (ER) human breast cancer cells. Ethanolic and aqueous extracts of leaves were tested for cytotoxicity against unstimulated normal human peripheral blood mononuclear cells (hPBMC), as well as against an ER human breast cancer cell line (BT-474) and an ER human breast cancer cell line (MDA-MB-231). An ethanolic leaf extract killed hPBMC, BT-474, and MDA-MB-231 cells with IC values of 23.6 ± 0.3, 27 ± 5, and 37 ± 4 μg/ml, respectively. An aqueous extract killed hPBMC with an IC value of 60 ± 10 μg/ml, but had no effect on the two cancer cell lines at concentrations up to 100 μg/ml. The results of this study indicate that the cytotoxicity of California mugwort extends to normal human cells, as well as cancerous cells. Therefore, until further is known about the safety of this medicine, caution should be taken when consuming extracts of California mugwort, whether as a tincture or as a tea.
加州艾（Besser）在加利福尼亚州的许多部落中被用于治疗多种病症，包括感冒、过敏和疼痛。加州艾也被用作女性药物。在原住民社区之外，其使用量正在上升，而且往往没有传统治疗师或经验丰富的草药师的指导。由于已证明它对植物和动物细胞具有抗增殖活性，我们研究了加州艾提取物对正常人类细胞以及雌激素受体阳性（ER）和雌激素受体阴性（ER）的人类乳腺癌细胞是否有影响。测试了叶片的乙醇提取物和水提取物对未受刺激的正常人类外周血单核细胞（hPBMC）以及对ER人类乳腺癌细胞系（BT - 474）和ER人类乳腺癌细胞系（MDA - MB - 231）的细胞毒性。乙醇叶提取物杀死hPBMC、BT - 474和MDA - MB - 231细胞的IC值分别为23.6±0.3、27±5和37±4μg/ml。水提取物杀死hPBMC的IC值为60±10μg/ml，但在浓度高达100μg/ml时对两种癌细胞系均无影响。这项研究的结果表明，加州艾的细胞毒性不仅延伸至癌细胞，还涉及正常人类细胞。因此，在进一步了解这种药物的安全性之前，食用加州艾提取物时应谨慎，无论是制成酊剂还是泡茶饮用。
