Metgud R, Gupta K, Gupta J
Department of Oral and Maxillofacial Pathology.
Biotech Histochem. 2014 Feb;89(2):153-9. doi: 10.3109/10520295.2013.831120. Epub 2013 Sep 30.
The oral cavity contains a unique and diverse microflora. While most of these organisms exhibit commensalism, shifts in bacterial community dynamics cause pathological changes within the oral cavity and at distant sites. We assessed the microbial flora using cultured saliva and oral swabs from subjects with oral squamous cell carcinoma (OSCC) and healthy controls. Microbial samples were collected from the carcinoma site, contralateral healthy mucosa, and saliva of the study group and samples were collected from healthy mucosa and saliva of controls. Samples were stored on ice and transported to the laboratory for culture. The median number of colony forming units (CFU)/ml at carcinoma sites was significantly greater than at the contralateral healthy mucosa. Similarly, in saliva of carcinoma subjects, the median number of CFU/ml was significantly greater than in saliva of control subjects.
口腔中存在独特且多样的微生物群落。虽然这些微生物大多表现为共生关系，但细菌群落动态的变化会导致口腔内及远处部位发生病理变化。我们使用培养的唾液和口腔拭子，对患有口腔鳞状细胞癌（OSCC）的受试者和健康对照者的微生物群进行了评估。微生物样本取自研究组的癌灶部位、对侧健康黏膜及唾液，对照组的样本取自健康黏膜和唾液。样本在冰上保存并运至实验室进行培养。癌灶部位每毫升菌落形成单位（CFU）的中位数显著高于对侧健康黏膜。同样，癌症受试者唾液中每毫升CFU的中位数也显著高于对照受试者唾液中的该数值。
