King Fahd Medical Research Centre, King Abdulaziz University, P.O. Box 80216, Jeddah 21589, Kingdom of Saudi Arabia.
CNS Neurol Disord Drug Targets. 2014 Apr;13(3):402-7. doi: 10.2174/18715273113126660150.
The present study compares the role and significance of non-high density lipoproteins (non-HDL) cholesterol level in pre-diabetic and diabetic patients. This study also compares non-HDL cholesterol level between males and females and with different age groups as well.
An observational study was conducted among 3830 randomly selected individuals to envisage the association of non-HDL cholesterol and other lipid parameters with age, gender, and diabetic status. On the basis of health status, the subjects were classified as diabetic, pre-diabetic and normal. Fasting blood samples were collected and analyzed on Roche p-800 modular system. Total cholesterol, high density lipoproteins (HDL), low density lipoproteins (LDL) and fasting triglycerides were also measured. From the above mentioned parameters, the level of non-HDL cholesterol level was also calculated.
Significant association was observed with non-HDL cholesterol level and all other studied lipid parameters (total cholesterol, HDL, LDL and triglycerides) compared with age and gender of the subjects studied. Moreover, the calculated non-HDL level, total cholesterol and triglycerides were found to be significantly co-related with diabetic status of the patients involved in the study. However, HDL and LDL values did not show any significant association with diabetic status of the patients.
In this study, we found that age and gender of the studied subjects are associated with non-HDL cholesterol. Moreover, our data clearly indicates the positive association of non-HDL cholesterol level with pre-diabetic and diabetic status of the patients. Based on our study, we recommend estimation of non-HDL level in routine clinical practice to differentiate pre-diabetic and diabetic patients.
本研究比较了非高密度脂蛋白（non-HDL）胆固醇水平在糖尿病前期和糖尿病患者中的作用和意义。本研究还比较了男性和女性以及不同年龄组之间的非高密度脂蛋白胆固醇水平。
对 3830 名随机选择的个体进行观察性研究，以预测非高密度脂蛋白胆固醇和其他脂质参数与年龄、性别和糖尿病状态的关系。根据健康状况，将受试者分为糖尿病、糖尿病前期和正常。采集空腹血样，用罗氏 p-800 模块系统进行分析。还测量了总胆固醇、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）和空腹甘油三酯。根据上述参数，还计算了非高密度脂蛋白胆固醇水平。
与研究对象的年龄和性别相比，非高密度脂蛋白胆固醇水平与所有其他研究的脂质参数（总胆固醇、HDL、LDL 和甘油三酯）均存在显著相关性。此外，计算出的非高密度脂蛋白水平、总胆固醇和甘油三酯与研究中患者的糖尿病状态密切相关。然而，HDL 和 LDL 值与患者的糖尿病状态无显著相关性。
在这项研究中，我们发现研究对象的年龄和性别与非高密度脂蛋白胆固醇有关。此外，我们的数据清楚地表明，非高密度脂蛋白胆固醇水平与糖尿病前期和糖尿病患者的状态呈正相关。基于我们的研究，我们建议在常规临床实践中估计非高密度脂蛋白水平，以区分糖尿病前期和糖尿病患者。
