Liu Jun-Ru, Liu Bo-Wei, Yin Fu-Zai
Department of Endocrinology, The First Hospital of Qinhuangdao, Hebei Medical University, Qinhuangdao, Hebei Province, China.
Medicine (Baltimore). 2017 Nov;96(44):e8461. doi: 10.1097/MD.0000000000008461.
This study aimed to observe the change in nonhigh-density lipoprotein cholesterol (non-HDL-C) levels and analyzed its related factors in adults with prediabetes (impaired fasting glucose and/or impaired glucose tolerance).This case-controlled study included 56 adults with normal glucose tolerance (NGT) and 74 adults with prediabetes. The cases and controls were age and gender-matched. Anthropometric measurements including height, weight, waist circumference, and blood pressure were performed. All patients underwent an oral glucose tolerance test (OGTT) after 8 hours of fasting, and the levels of glucose, insulin, lipids, and uric acid were measured.The levels of non-HDL-C (3.63 ± 0.92 vs 3.27 ± 1.00 mmol/L) were significantly higher in prediabetic subjects than in NGT subjects (P < .05). Non-HDL-C positively correlated with HOMA-IR (r = 0.253, P = .004), triglyceride (r = 0.204, P = .020), and uric acid (r = 0.487, P = .000). After multivariate analysis, uric acid continued to be significantly associated with non-HDL-C (β = 0.006, P = .000).Non-HDL-C is elevated in adults with prediabetes. A relationship between non-HDL-C and uric acid was observed.
本研究旨在观察糖尿病前期（空腹血糖受损和/或糖耐量受损）成人中非高密度脂蛋白胆固醇（non-HDL-C）水平的变化，并分析其相关因素。这项病例对照研究纳入了56例糖耐量正常（NGT）的成人和74例糖尿病前期成人。病例组和对照组在年龄和性别上相匹配。进行了包括身高、体重、腰围和血压在内的人体测量。所有患者在禁食8小时后进行口服葡萄糖耐量试验（OGTT），并测量血糖、胰岛素、血脂和尿酸水平。糖尿病前期受试者的non-HDL-C水平（3.63±0.92 vs 3.27±1.00 mmol/L）显著高于NGT受试者（P<0.05）。Non-HDL-C与HOMA-IR（r=0.253，P=0.004）、甘油三酯（r=0.204，P=0.020）和尿酸（r=0.487，P=0.000）呈正相关。多变量分析后，尿酸仍与non-HDL-C显著相关（β=0.006，P=0.000）。糖尿病前期成人的non-HDL-C升高。观察到non-HDL-C与尿酸之间存在关联。
