Yellowlees P M, Kalucy R S
Broken Hill Base Hospital, New South Wales.
Chest. 1990 Mar;97(3):628-34. doi: 10.1378/chest.97.3.628.
Recent research suggests that anxiety disorders are more common in asthmatic patients than in the population as a whole. There are a variety of biologic, psychologic, and social factors that suggest that the disorder of asthma may in itself be anxiogenic and that simply having asthma may give patients an increased vulnerability toward the development of anxiety disorders. These issues are reviewed and emphasis is placed on the need for further research into the apparent biologic areas of overlap between psychiatric disorders and asthma. It is hypothesized that a "lactate challenge test" may be used in asthmatics to see if they are predisposed to panic and suggested that a therapeutic trial of tricyclic antidepressants in anxious asthmatics is indicated. Research into the psychobiologic aspects of asthma is likely to clarify the role of "emotional" factors in asthma and may well have significant implications for the management of this disorder.
近期研究表明，焦虑症在哮喘患者中比在整个人口中更为常见。存在多种生物、心理和社会因素，表明哮喘疾病本身可能具有致焦虑性，仅仅患有哮喘可能会使患者更容易患上焦虑症。本文对这些问题进行了综述，并强调有必要进一步研究精神疾病和哮喘之间明显的生物重叠领域。据推测，“乳酸激发试验”可用于哮喘患者，以查看他们是否易患恐慌症，并建议对焦虑的哮喘患者进行三环类抗抑郁药的治疗试验。对哮喘心理生物学方面的研究可能会阐明“情绪”因素在哮喘中的作用，并且很可能对这种疾病的管理产生重大影响。
