Boland Paul W, Watt-Smith Steve R, Hopper Colin, Golding Stephen J
Radiology Group, Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headley Way, Headington, Oxford OX3 9DU, UK.
Br J Oral Maxillofac Surg. 2013 Dec;51(8):696-701. doi: 10.1016/j.bjoms.2013.09.001. Epub 2013 Sep 27.
The purpose of this study was to investigate the effectiveness of tumour variables measured on magnetic resonance imaging (MRI) to predict 2-year disease-related survival and occult cervical lymph node metastasis in oral carcinoma. In this retrospective, dual-centre study the volume and thickness of tumours were measured using archived MRI staging scans of 199 patients who had curative primary resection for histologically confirmed oral carcinoma. Tumour volume predicted survival when grouped using the median (3.0 cm(3), HR 3.41, p 0.005) and first and third quartiles (0.5 cm(3), HR 8.22, p 0.04; 8.0 cm(3), HR 18.6, p 0.005). Tumour thickness predicted survival using a median of 11.0 mm (HR 2.65, p 0.02). Volume predicted occult cervical lymph node metastasis using a median of 3.0 cm(3) (HR 5.02, p<0.001) and quartiles of 0.5 cm(3) (HR 6.92, p=0.01) and 8.0 cm(3) (HR 11.3, p 0.005); thickness predicted it using a median of 11.0 mm (HR 4.39, p 0.002) and quartiles of 4.0 mm (HR 4.33, p 0.06) and 16 mm (HR 11.9, p 0.003). The thickness and volume of tumour measured on MRI may predict 2-year disease-related survival and occult cervical lymph node metastasis in oral cancer.
本研究旨在探讨磁共振成像（MRI）测量的肿瘤变量对预测口腔癌2年疾病相关生存率和隐匿性颈部淋巴结转移的有效性。在这项回顾性双中心研究中，使用199例经组织学确诊为口腔癌并接受根治性原发灶切除患者的存档MRI分期扫描测量肿瘤的体积和厚度。当按中位数（3.0 cm³，HR 3.41，p 0.005）以及第一和第三四分位数（0.5 cm³，HR 8.22，p 0.04；8.0 cm³，HR 18.6，p 0.005）分组时，肿瘤体积可预测生存率。肿瘤厚度以11.0 mm为中位数时可预测生存率（HR 2.65，p 0.02）。体积以3.0 cm³为中位数时可预测隐匿性颈部淋巴结转移（HR 5.02，p<0.001），四分位数0.5 cm³（HR 6.92，p=0.01）和8.0 cm³（HR 11.3，p 0.005）也可；厚度以11.0 mm为中位数时可预测（HR 4.39，p 0.002），四分位数4.0 mm（HR 4.33，p 0.06）和16 mm（HR 11.9，p 0.003）也可。MRI测量的肿瘤厚度和体积可能预测口腔癌的2年疾病相关生存率和隐匿性颈部淋巴结转移。
