Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
J Am Acad Dermatol. 2013 Dec;69(6):1003-13. doi: 10.1016/j.jaad.2013.06.046. Epub 2013 Sep 26.
Patients with moderate to severe psoriasis often require systemic immunomodulatory medications that place them at risk for infection. Vaccination is a proven strategy to reduce infections. However, vaccination rates among patients with inflammatory autoimmune conditions, including psoriasis, remain low. We review the literature regarding vaccine-preventable illness and vaccinations commonly used in the United States in patients older than 18 years on immunosuppressive therapies that are used in the treatment of psoriasis. The medical board of the National Psoriasis Foundation recommends that dermatologists counsel patients on updating vaccinations in accordance with recommendations of the Advisory Committee for Immunization Practices as any measures taken to prevent infection can increase the safety of immunomodulatory therapies.
患有中度至重度银屑病的患者通常需要全身性免疫调节药物,这使他们面临感染的风险。疫苗接种是减少感染的一种经过验证的策略。然而,包括银屑病在内的炎症性自身免疫性疾病患者的疫苗接种率仍然很低。我们回顾了有关可通过疫苗预防的疾病和在美国 18 岁以上接受免疫抑制疗法治疗银屑病的患者中常用疫苗的文献。国家银屑病基金会医学委员会建议皮肤科医生根据免疫实践咨询委员会的建议为患者提供有关更新疫苗接种的建议,因为任何预防感染的措施都可以提高免疫调节疗法的安全性。