ANSES, Ploufragan-Plouzané Laboratory, BP 53, 22440 Ploufragan, France; Université européenne de Bretagne, Rennes, France.
Int J Antimicrob Agents. 2013 Nov;42(5):379-83. doi: 10.1016/j.ijantimicag.2013.06.012. Epub 2013 Sep 26.
Colistin is a cyclic decapeptide bound to a fatty acid chain. It is active against many Gram-negative bacteria by destabilising the bacterial outer membrane. Bacteria can become resistant to colistin by modification of their lipopolysaccharide, thereby reducing the affinity of polymyxins. Colistin is often administered orally in poultry and pig production to control colibacillosis. Resistant isolates are sometimes recovered from pathological cases, particularly in piglets. However, in Europe the percentage of resistance to colistin in Escherichia coli strains isolated from the digestive tract microbiota of healthy animals remains <1%.
黏菌素是一种与脂肪酸链结合的环十肽。它通过破坏细菌的外膜来对抗许多革兰氏阴性菌。细菌可以通过改变其脂多糖来对抗黏菌素，从而降低多黏菌素的亲和力。黏菌素常用于家禽和猪生产中口服控制大肠杆菌病。耐药分离株有时从病料中回收，特别是在仔猪中。然而，在欧洲，从健康动物消化道微生物群中分离的大肠杆菌菌株对黏菌素的耐药率仍<1%。
