Michigami Toshimi
Department of Bone and Mineral Research, Osaka Medical Center and Research Institute for Maternal and Child Health, Japan.
Clin Calcium. 2013 Oct;23(10):1429-35.
Some of the hypophosphatemic rickets/osteomalacia are caused by the increased bioactivity of FGF23, and classified into FGF23-mediated hypophosphatemic rickets/osteomalacia. This group includes various disorders such as X-linked, autosomal dominant and autosomal recessive hypophosphatemic rickets/osteomalacia, tumor-induced osteomalacia, and rickets/osteomalacia caused by the administration of iron polymaltose or saccharated ferric oxide. Measurement of serum levels of FGF23 is useful for diagnosis of these conditions. In the adult patients with FGF23-mediated hypophosphatemic rickets/osteomalacia, mineralizing enthesoopathy is an often observed complication.
一些低磷性佝偻病/骨软化症是由成纤维细胞生长因子23（FGF23）生物活性增加引起的，被归类为FGF23介导的低磷性佝偻病/骨软化症。这一组包括各种疾病，如X连锁、常染色体显性和常染色体隐性低磷性佝偻病/骨软化症、肿瘤诱导的骨软化症以及因服用聚麦芽糖铁或含糖氧化铁引起的佝偻病/骨软化症。检测血清FGF23水平有助于诊断这些疾病。在患有FGF23介导的低磷性佝偻病/骨软化症的成年患者中，矿化附着点病是一种常见的并发症。
